Target : Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase

Total records found: 23

Download:

Search:

AptBacDB_ID ⇅	PMID/DOI ⇅	Year ⇅	Title ⇅	Aptamer name ⇅	Sequence (5′ to 3′) ⇅	Length ⇅	Library ⇅	Type ⇅	Target Organism ⇅	Target ⇅	Objective/Mechanism ⇅	Outcome/Inhibitory effect ⇅	No. of selection round SELEX ⇅	Determination of affinity method ⇅	Kd value ⇅	Activity Role ⇅	Method ⇅	Modification ⇅	Cytotoxicity (cell viability) ⇅	Stability⇅	Potential Candidate ⇅	Half-life ⇅	Patent ⇅
ABdb_1467	32980107	2020	A novel method combining aptamer-Ag10NPs based microfluidic biochip with bright field imaging for detection of KPC-2-expressing bacteria	XK10	GGCAGGACACCGTAACGGGTATGCAGCTATCCCGGGCGCTGTCTGAAGATCGTGTGCTGCT	61	N/A	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Developed a PDMS/glass microfluidic biochip integrated with aptamer-modified Ag(10)NPs nano-biosensors to detect whether bacteria express KPC-2.	Detects the target bacterium with a detection limit of 10(2) CFU and a capture efficiency exceeding 90% in ∼1 h.	8	Surface Plasmon Resonance (SPR)	0.81 nM	Biosensor	Protein SELEX and Whole Cell-SELEX	5'-Biotinylated and 5′-Thiolated (SH-AAAAA) and 5'-FAM Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1504	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-10 (truncated)	GGCAGGACACCGTAACGGGTATGCAGCTATCCCGGGCGCTGTCTGAAGATCGTGTGCTGCT	61	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	The detection limit of Biotin-XK-10 was 104 CFU/mL, and that of Biotin-Ag-XK-10 was 103 CFU/mL.	4	Surface Plasmon Resonance (SPR) and Microarray Chip	0.81 ± 0.13 nM (by SPR) and 12.9 ± 1.03 nM (by microarray chip)	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	Best Candidate	N/A	N/A
ABdb_1505	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-1	ACCCCATATCGCGTCAAATTTGGCTACCTCACATGCCCAC	40	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1506	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-2	GACAGGCAGGACACCGTAAC-AAGCCCGTGCGGCTTCGTGCGATGGATACAGTGGGCGGGG-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1507	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-3	GACAGGCAGGACACCGTAAC-ACTAGTAACCCCTAACATCTTCCGCGTTCTTATAGGCCCC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1508	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-4	GACAGGCAGGACACCGTAAC-ACTCCATGGGGTTTGTAGGGCTCGCTGTAATTATACTTTA-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1509	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-5	GACAGGCAGGACACCGTAAC-ACTCCCCCTTCCCTGTCTGCTCTACCTGCCTGTTCCCTGC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1510	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-6	GACAGGCAGGACACCGTAAC-AGGTTGTTGCCGCTCCCCTCGTCTGTTGGGGGTTGTCCTC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1511	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-7	GACAGGCAGGACACCGTAAC-ATAACTTCTCTCCCGTCAGTCTCCGCAGCCCCATTCCATC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1512	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-8	GACAGGCAGGACACCGTAAC-ATCGCAGGGCCCCCGTTATTATTCCCCACTTCCTTCTGTC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1513	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-9	GACAGGCAGGACACCGTAAC-CGGGCTTATCGGTCCGTCTGGAAGGTCCTTTCCTATTCGC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1514	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-10	GACAGGCAGGACACCGTAAC-GGGTATGCAGCTATCCCGGGCGCTGTCTGAAGATCGTGTG-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1515	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-11	GACAGGCAGGACACCGTAAC-GGGTATACAGCTATCCCGGGCGCTGTCTGAAGATCGTGTG-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1516	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-12	GACAGGCAGGACACCGTAAC-GGGTATGCAGCTATCCCGGGCGCTGTCTGAAGATCGTGTC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1517	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-13	GACAGGCAGGACACCGTAAC-GGGTACGCAGCTATCCCGGGCGCTGTCTGAAGATCGTGTG-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1518	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-14	GACAGGCAGGACACCGTAAC-GTACTGCCTCCCTCCTGCCGTCCCTCTCTCTAGTCTCTGC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1519	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-15	GACAGGCAGGACACCGTAAC-GTCCGCCTCTGTATTCCTGCCTCTGTTCCTGCCTTCTGTC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1520	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-16	GACAGGCAGGACACCGTAAC-TATACCTTCCATCCCGGTCCTGCTCCTCGTCTTTTGTGTC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1521	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-17	GACAGGCAGGACACCGTAAC-TCCCACCTCTTCCCCCCTTCTAGGTTCATCTCGCGCCACC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1522	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-18	GACAGGCAGGACACCGTAAC-TCGTCATTCGTCATTCCTGCCCTTTCCTGCCTGATCTGTC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1523	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-19	GACAGGCAGGACACCGTAAC-TGCCCTCCCTTCCTGCCTGGTCCTGCCGTATTATTTTGTC-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1524	33379005	2021	Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX	XK-20	GACAGGCAGGACACCGTAAC-TTTCCTGTATTGTGGAAGTAAACGTCTGAGTGGTCGATGT-CTGCTACCTCCCTCCTCTTC	80	5'-GACAGGCAGGACACCGTAAC-N40-CTGCTACCTCCCTCCTCTTC-3' (Library I) and 5'-GACAGGCAGGACACCGTAACNNNGTCCNNNNNGGACNNGCCNNNNGGCNNNGTTACGGTGCTGCTACCTCCCTCCTCTTC-3' (Library II)	ssDNA	Escherichia Coli expressing KPC-2 (KPC-2 E. Coli)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Identify aptamers that specifically recognize KPC-2 and KPC-2 E. coli.	N/A	4	Surface Plasmon Resonance (SPR) and Microarray Chip	N/A	Biosensor	Precision-SELEX (Protein SELEX and Whole Cell-SELEX)	Biotinylated or FITC or TAMRA Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_1908	40801776	2025	Ultrasensitive Aptamer-Based Metal-Organic Framework-on-Metal-Organic Framework Platform for Clinical Detection of KPC-2 Klebsiella pneumoniae and Multidrug-Resistant Acinetobacter baumannii	KPC-2 KP aptamer	GGCAGGACACCGTAACGGGTATGCAGCTATCCCGGGCGCTGTCTGAAGATCGTGTGCTGC	60	N/A	ssDNA	Klebsiella Pneumoniae carbapenemase 2-expressing K. Pneumoniae (KPC-2 KP)	Klebsiella Pneumoniae Carbapenemase 2 (KPC-2) serine β-lactamase	Developed a dual nanozyme-powered colorimetric aptasensor leveraging a cascade amplification mechanism, a metal-organic framework (MOF)-on-MOF nanostructure with peroxidase-like activity for detection of KPC-2 K. pneumoniae and MDR-AB.	The system achieves selective bacterial capture within 40 min, quantifying 10–10(8) CFU/mL with a detection limit of 7 CFU/mL for KPC-2 KP.	N/A	N/A	N/A	Biosensor	N/A	5'-FAM Labeled	N/A	N/A	N/A	N/A	N/A