Target : Flagella

Total records found: 8

Download:

Search:

AptBacDB_ID ⇅	PMID/DOI ⇅	Year ⇅	Title ⇅	Aptamer name ⇅	Sequence (5′ to 3′) ⇅	Length ⇅	Library ⇅	Type ⇅	Target Organism ⇅	Target ⇅	Objective/Mechanism ⇅	Outcome/Inhibitory effect ⇅	No. of selection round SELEX ⇅	Determination of affinity method ⇅	Kd value ⇅	Activity Role ⇅	Method ⇅	Modification ⇅	Cytotoxicity (cell viability) ⇅	Stability⇅	Potential Candidate ⇅	Half-life ⇅	Patent ⇅
ABdb_0502	26025307	2015	Efficient suppression of biofilm formation by a nucleic acid aptamer	Aptamer 3	GGGAGCTCAGAATAAACGCTCAA-GGCAGGACAACAGCGTGTAGTATCAGCTTACGGTG-TTCGACATGAGGCCCGGATC	78	5'-GGGAGCTCAGAATAAACGCTCAA-N35-TTCGACATGAGGCCCGGATC-3'	ssDNA	Salmonella Choleraesuis	Flagella	Identify an aptamer that binds to flagella and inhibits biofilm formation by restricting its rotational frequency and covering its binding sites that attach to the matrix surfaces.	13.8% survival ratio of living cells in biofilms with 1.1 μM aptamer and 5 μg/mL ampicillin sodium.	14	Fluorescence Spectroscopy	41 ± 2 nM	Therapeutics	SELEX	FITC Labeled	N/A	N/A	Best Candidate	N/A	N/A
ABdb_0503	26025307	2015	Efficient suppression of biofilm formation by a nucleic acid aptamer	Aptamer 1	GGGAGCTCAGAATAAACGCTCAA-GGCCAGCAGCGAGTGTGGAGTATTGTGTTGTGGTG-TTCGACATGAGGCCCGGATC	78	5'-GGGAGCTCAGAATAAACGCTCAA-N35-TTCGACATGAGGCCCGGATC-3'	ssDNA	Salmonella Choleraesuis	Flagella	Identify an aptamer that binds to flagella and inhibits biofilm formation by restricting its rotational frequency and covering its binding sites that attach to the matrix surfaces.	N/A	14	Fluorescence Spectroscopy	50 ± 2 nM	Therapeutics	SELEX	FITC Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_0504	26025307	2015	Efficient suppression of biofilm formation by a nucleic acid aptamer	Aptamer 2	GGGAGCTCAGAATAAACGCTCAA-GGGCAGGTGTTATGTGTACTGCTACAGTGTGGTTG-TTCGACATGAGGCCCGGATC	78	5'-GGGAGCTCAGAATAAACGCTCAA-N35-TTCGACATGAGGCCCGGATC-3'	ssDNA	Salmonella Choleraesuis	Flagella	Identify an aptamer that binds to flagella and inhibits biofilm formation by restricting its rotational frequency and covering its binding sites that attach to the matrix surfaces.	N/A	14	Fluorescence Spectroscopy	54 ± 2 nM	Therapeutics	SELEX	FITC Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_0505	26025307	2015	Efficient suppression of biofilm formation by a nucleic acid aptamer	Aptamer 4	GGGAGCTCAGAATAAACGCTCAA-GGCACGGCATGTGTGGTATGTGGTGCCTGTACTCG-TTCGACATGAGGCCCGGATC	78	5'-GGGAGCTCAGAATAAACGCTCAA-N35-TTCGACATGAGGCCCGGATC-3'	ssDNA	Salmonella Choleraesuis	Flagella	Identify an aptamer that binds to flagella and inhibits biofilm formation by restricting its rotational frequency and covering its binding sites that attach to the matrix surfaces.	N/A	14	Fluorescence Spectroscopy	53 ± 5 nM	Therapeutics	SELEX	FITC Labeled	N/A	N/A	N/A	N/A	N/A
ABdb_0823	28069377	2017	Development of an aptamer-ampicillin conjugate for treating biofilms	Aptamer 3	GGGAGCTCAGAATAAACGCTCAA-GGCAGGACAACAGCGTGTAGTATCAGCTTACGGTG-TTCGACATGAGGCCCGGATC	78	N/A	ssDNA	Salmonella Choleraesuis	Flagella	Aptamer-ampicillin conjugate (Apt3-Amp) to inhibit biofilm formation.	Biofilms containing the conjugate had the lowest survival ratio (37.22 ± 1.12%) compared with control conjugates.	14	Fluorescence Spectroscopy	41 ± 2 nM	Therapeutics	Whole Cell-SELEX	3'-Amidation (NH₂) and 5'-FITC Labeled	N/A	N/A	Best Candidate	N/A	N/A
ABdb_0824	28069377	2017	Development of an aptamer-ampicillin conjugate for treating biofilms	Aptamer 1	GGGAGCTCAGAATAAACGCTCAA-GGCCAGCAGCGAGTGTGGAGTATTGTGTTGTGGTG-TTCGACATGAGGCCCGGATC	78	N/A	ssDNA	Salmonella Choleraesuis	Flagella	Aptamer-ampicillin conjugate (Apt3-Amp) to inhibit biofilm formation.	N/A	14	Fluorescence Spectroscopy	50 ± 2 nM	Therapeutics	Whole Cell-SELEX	N/A	N/A	N/A	N/A	N/A	N/A
ABdb_0825	28069377	2017	Development of an aptamer-ampicillin conjugate for treating biofilms	Aptamer 2	GGGAGCTCAGAATAAACGCTCAA-GGGCAGGTGTTATGTGTACTGCTACAGTGTGGTTG-TTCGACATGAGGCCCGGATC	78	N/A	ssDNA	Salmonella Choleraesuis	Flagella	Aptamer-ampicillin conjugate (Apt3-Amp) to inhibit biofilm formation.	N/A	14	Fluorescence Spectroscopy	54 ± 2 nM	Therapeutics	Whole Cell-SELEX	N/A	N/A	N/A	N/A	N/A	N/A
ABdb_0826	28069377	2017	Development of an aptamer-ampicillin conjugate for treating biofilms	Aptamer 4	GGGAGCTCAGAATAAACGCTCAA-GGCACGGCATGTGTGGTATGTGGTGCCTGTACTCG-TTCGACATGAGGCCCGGATC	78	N/A	ssDNA	Salmonella Choleraesuis	Flagella	Aptamer-ampicillin conjugate (Apt3-Amp) to inhibit biofilm formation.	N/A	14	Fluorescence Spectroscopy	53 ± 5 nM	Therapeutics	Whole Cell-SELEX	N/A	N/A	N/A	N/A	N/A	N/A