AptBacterialDB

Target : Fibronectin-binding Protein A (FnbA)

Total records found: 2

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AptBacDB_ID ⇅ PMID/DOI ⇅ Year ⇅ Title ⇅ Aptamer name ⇅ Sequence (5′ to 3′) ⇅ Length ⇅ Library ⇅ Type ⇅ Target Organism ⇅ Target ⇅ Objective/Mechanism ⇅ Outcome/Inhibitory effect ⇅ No. of selection round SELEX ⇅ Determination of affinity method ⇅ Kd value ⇅ Activity Role ⇅ Method ⇅ Modification ⇅ Cytotoxicity (cell viability) ⇅ Stability⇅ Potential Candidate ⇅ Half-life ⇅ Patent ⇅
ABdb_1995 249357142014Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components4726–44N/AN/AN/AssDNAStaphylococcus aureus (S. aureus) NRS384 (USA300)Fibronectin-binding Protein A (FnbA)Developed slow off-rate modified aptamer (SOMAmer) reagents to several Staphylococcus aureus cell surface-associated proteins via SELEX.N/A8Radiolabel Filter Binding Assay4·38 nMDetectionSELEXNapdU (5-naphthylmethyl-aminocarbonyl-dU) and 5′biotin-dA or 5′fluorescein-biotin-dA and 3’-Inverted Thymidine (3'-idT)N/AN/AN/AN/AN/A
ABdb_1996 249357142014Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components4745–51N/AN/AN/AssDNAStaphylococcus aureus (S. aureus) NRS384 (USA300)Fibronectin-binding Protein A (FnbA)Developed slow off-rate modified aptamer (SOMAmer) reagents to several Staphylococcus aureus cell surface-associated proteins via SELEX.N/A8Radiolabel Filter Binding Assay0·63 nMDetectionSELEXTrpdU (5-tryptaminocarbonyl-dU) and 5′biotin-dA or 5′fluorescein-biotin-dA and 3’-Inverted Thymidine (3'-idT)N/AN/AN/AN/AN/A