Target : DevR protein

Total records found: 7

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AptBacDB_ID ⇅	PMID/DOI ⇅	Year ⇅	Title ⇅	Aptamer name ⇅	Sequence (5′ to 3′) ⇅	Length ⇅	Library ⇅	Type ⇅	Target Organism ⇅	Target ⇅	Objective/Mechanism ⇅	Outcome/Inhibitory effect ⇅	No. of selection round SELEX ⇅	Determination of affinity method ⇅	Kd value ⇅	Activity Role ⇅	Method ⇅	Modification ⇅	Cytotoxicity (cell viability) ⇅	Stability⇅	Potential Candidate ⇅	Half-life ⇅	Patent ⇅
ABdb_1664	36332135	2022	DNA Aptamer Targets Mycobacterium tuberculosis DevR/DosR Response Regulator Function by Inhibiting Its Dimerization and DNA Binding Activity	R6DevR22 (APT-1)	GTCTTGACTAGTTACGCC-CTGCTGGTCTTTAGTCTCTATTGAGTGGCTAAAGTTGAGGCAG-TCATTCAGTTGGCGCCTC	79	5'-GTCTTGACTAGTTACGCC-N44-TCATTCAGTTGGCGCCTC-3'	ssDNA	Mycobacterium Tuberculosis (M.Tb.)	DevR protein	Identify an aptamer against DevR and inhibit DevR-dependent transcription by blocking DevR dimerisation and DNA-binding activity in Mycobacterium smegmatis.	APT-1, APT-2, APT-5, and APT-7 exhibited a maximum of ∼40% inhibition of Rv1738 promoter activity.	8	Aptamer-Linked Immobilized Sorbent Assay (ALISA)	N/A	Therapeutics	Subtractive Nitrocellulose Membrane (NCM)-based SELEX	5'-Biotinylated	N/A	N/A	N/A	N/A	N/A
ABdb_1665	36332135	2022	DNA Aptamer Targets Mycobacterium tuberculosis DevR/DosR Response Regulator Function by Inhibiting Its Dimerization and DNA Binding Activity	R6DevR25 (APT-2)	GTCTTGACTAGTTACGCC-CTGCCTTTTCAAAAGTTTATTGGGATGTACTTTTGTTCAGGCAG-TCATTCAGTTGGCGCCTC	80	5'-GTCTTGACTAGTTACGCC-N44-TCATTCAGTTGGCGCCTC-3'	ssDNA	Mycobacterium Tuberculosis (M.Tb.)	DevR protein	By targeting DevR dimerization, it blocks the essential step in DevR activation, thus intercepting dormancy pathways in mycobacteria.	APT-1, APT-2, APT-5, and APT-7 exhibited a maximum of ∼40% inhibition of Rv1738 promoter activity.	8	Aptamer-Linked Immobilized Sorbent Assay (ALISA)	N/A	Therapeutics	Subtractive Nitrocellulose Membrane (NCM)-based SELEX	5'-Biotinylated	N/A	N/A	N/A	N/A	N/A
ABdb_1666	36332135	2022	DNA Aptamer Targets Mycobacterium tuberculosis DevR/DosR Response Regulator Function by Inhibiting Its Dimerization and DNA Binding Activity	R6DevR28 (APT-3)	GTCTTGACTAGTTACGCC-CATAAACGCAGTGACGTTCCCAGAATTGTGGCTGATGATTTTGG-TCATTCAGTTGGCGCCTC	80	5'-GTCTTGACTAGTTACGCC-N44-TCATTCAGTTGGCGCCTC-3'	ssDNA	Mycobacterium Tuberculosis (M.Tb.)	DevR protein	By targeting DevR dimerization, it blocks the essential step in DevR activation, thus intercepting dormancy pathways in mycobacteria.	N/A	8	Aptamer-Linked Immobilized Sorbent Assay (ALISA)	N/A	Therapeutics	Subtractive Nitrocellulose Membrane (NCM)-based SELEX	5'-Biotinylated	N/A	N/A	N/A	N/A	N/A
ABdb_1667	36332135	2022	DNA Aptamer Targets Mycobacterium tuberculosis DevR/DosR Response Regulator Function by Inhibiting Its Dimerization and DNA Binding Activity	R6DevR10 (APT-4)	GTCTTGACTAGTTACGCC-GCGAGAATGTGCGCAAAGTCTCATGTCAGTATGTGGTCTTTTCG-TCATTCAGTTGGCGCCTC	80	5'-GTCTTGACTAGTTACGCC-N44-TCATTCAGTTGGCGCCTC-3'	ssDNA	Mycobacterium Tuberculosis (M.Tb.)	DevR protein	By targeting DevR dimerization, it blocks the essential step in DevR activation, thus intercepting dormancy pathways in mycobacteria.	APT-4 inhibited Rv1738 promoter activity in a time-dependent manner, with an inhibition value of 61% at 96 hours and inhibited DevR–DevR interaction in vivo by ∼35%.	8	Aptamer-Linked Immobilized Sorbent Assay (ALISA)	N/A	Therapeutics	Subtractive Nitrocellulose Membrane (NCM)-based SELEX	5'-Biotinylated	N/A	N/A	N/A	N/A	N/A
ABdb_1668	36332135	2022	DNA Aptamer Targets Mycobacterium tuberculosis DevR/DosR Response Regulator Function by Inhibiting Its Dimerization and DNA Binding Activity	R7DevR16 (APT-5)	GTCTTGACTAGTTACGCC-CTGCCTTGGCTCGAAGGGGTGATGAGAAGTAGGCGGGAAGGCAG-TCATTCAGTTGGCGCCTC	80	5'-GTCTTGACTAGTTACGCC-N44-TCATTCAGTTGGCGCCTC-3'	ssDNA	Mycobacterium Tuberculosis (M.Tb.)	DevR protein	By targeting DevR dimerization, it blocks the essential step in DevR activation, thus intercepting dormancy pathways in mycobacteria.	APT-1, APT-2, APT-5, and APT-7 exhibited a maximum of ∼40% inhibition of Rv1738 promoter activity.	8	Aptamer-Linked Immobilized Sorbent Assay (ALISA)	N/A	Therapeutics	Subtractive Nitrocellulose Membrane (NCM)-based SELEX	5'-Biotinylated	N/A	N/A	N/A	N/A	N/A
ABdb_1669	36332135	2022	DNA Aptamer Targets Mycobacterium tuberculosis DevR/DosR Response Regulator Function by Inhibiting Its Dimerization and DNA Binding Activity	R7DevR28 (APT-6)	GTCTTGACTAGTTACGCC-CGAGGGGAAGGATGGGGTGGAGGGAGGTGGGGGAGGGTTGGTGG-TCATTCAGTTGGCGCCTC	80	5'-GTCTTGACTAGTTACGCC-N44-TCATTCAGTTGGCGCCTC-3'	ssDNA	Mycobacterium Tuberculosis (M.Tb.)	DevR protein	By targeting DevR dimerization, it blocks the essential step in DevR activation, thus intercepting dormancy pathways in mycobacteria.	APT-6 inhibited Rv1738 promoter activity in a time-dependent manner, with an inhibition value of 66% at 96 hours and inhibited DevR–DevR interaction in vivo by ∼35%.	8	Aptamer-Linked Immobilized Sorbent Assay (ALISA)	4.724 nM	Therapeutics	Subtractive Nitrocellulose Membrane (NCM)-based SELEX	5'-Biotinylated	N/A	N/A	Best Candidate	N/A	N/A
ABdb_1670	36332135	2022	DNA Aptamer Targets Mycobacterium tuberculosis DevR/DosR Response Regulator Function by Inhibiting Its Dimerization and DNA Binding Activity	R7DevR29 (APT-7)	GTCTTGACTAGTTACGCC-CCCAAGAACCCGCTCGCCGTGGTGACGTCGATCATGCCTTTTGG-TCATTCAGTTGGCGCCTC	80	5'-GTCTTGACTAGTTACGCC-N44-TCATTCAGTTGGCGCCTC-3'	ssDNA	Mycobacterium Tuberculosis (M.Tb.)	DevR protein	By targeting DevR dimerization, it blocks the essential step in DevR activation, thus intercepting dormancy pathways in mycobacteria.	APT-1, APT-2, APT-5, and APT-7 exhibited a maximum of ∼40% inhibition of Rv1738 promoter activity.	8	Aptamer-Linked Immobilized Sorbent Assay (ALISA)	N/A	Therapeutics	Subtractive Nitrocellulose Membrane (NCM)-based SELEX	5'-Biotinylated	N/A	N/A	N/A	N/A	N/A