Target : DNAK (Rv0350 gene)

Total records found: 2

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AptBacDB_ID ⇅	PMID/DOI ⇅	Year ⇅	Title ⇅	Aptamer name ⇅	Sequence (5′ to 3′) ⇅	Length ⇅	Library ⇅	Type ⇅	Target Organism ⇅	Target ⇅	Objective/Mechanism ⇅	Outcome/Inhibitory effect ⇅	No. of selection round SELEX ⇅	Determination of affinity method ⇅	Kd value ⇅	Activity Role ⇅	Method ⇅	Modification ⇅	Cytotoxicity (cell viability) ⇅	Stability⇅	Potential Candidate ⇅	Half-life ⇅	Patent ⇅
ABdb_2066	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	7606-49	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	DNAK (Rv0350 gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	Exhibit LOD of 0.59 pM, 1.53 pM, 2.19 pM and 1.6 × 10(7) cells/ml in Buffer, Normal serum(40%), Urine protein (100 μg) and serum bacterial load, respectively.	N/A	Radiolabel Equilibration Binding Assay	0.66 nM	Biosensor	N/A	TrpdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	Best Candidate	N/A	N/A
ABdb_2067	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	14486-2	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	DNAK (Rv0350 gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	Exhibit LOD of 0.31 pM, 0.78 pM, 3.03 pM and 7.4 × 10(6) cells/ml in Buffer, Normal serum(40%), Urine protein (100 μg) and serum bacterial load, respectively.	N/A	Radiolabel Equilibration Binding Assay	1.03 nM	Biosensor	N/A	2NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	Best Candidate	N/A	N/A