Target : CE (Culture filtrate protein (CFP10) and Early secreted antigenic target (ESAT6)) proteins

Total records found: 2

Download:

Search:

AptBacDB_ID ⇅	PMID/DOI ⇅	Year ⇅	Title ⇅	Aptamer name ⇅	Sequence (5′ to 3′) ⇅	Length ⇅	Library ⇅	Type ⇅	Target Organism ⇅	Target ⇅	Objective/Mechanism ⇅	Outcome/Inhibitory effect ⇅	No. of selection round SELEX ⇅	Determination of affinity method ⇅	Kd value ⇅	Activity Role ⇅	Method ⇅	Modification ⇅	Cytotoxicity (cell viability) ⇅	Stability⇅	Potential Candidate ⇅	Half-life ⇅	Patent ⇅
ABdb_2010	24968239	2014	CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents	CE24	N/A	N/A	5'-GCGGAATTCTAATACGACTCACTATAGGGA ACAGTCCCGAGCC-N30-GGGTCAATGCGTCATA-3'	ssDNA	Mycobacterium Tuberculosis (M.Tb.)	CE (Culture filtrate protein (CFP10) and Early secreted antigenic target (ESAT6)) proteins	Identify aptamers against CE proteins and develop an aptamer-based ELONA assay for detection in serum samples.	Sensitivity and specificity using CE24 aptamer-based ELONA) were 100% and 94.1%.	15	Enzyme-Linked Immunosorbent Assay (ELISA)	3.75 × 10(−7) M	Detection	SELEX	Biotinylated	N/A	N/A	N/A	N/A	N/A
ABdb_2011	24968239	2014	CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents	CE15	N/A	N/A	5'-GCGGAATTCTAATACGACTCACTATAGGGA ACAGTCCCGAGCC-N30-GGGTCAATGCGTCATA-3'	ssDNA	Mycobacterium Tuberculosis (M.Tb.)	CE (Culture filtrate protein (CFP10) and Early secreted antigenic target (ESAT6)) proteins	Identify aptamers against CE proteins and develop an aptamer-based ELONA assay for detection in serum samples.	Sensitivity and specificity using CE15 aptamer-based ELONA) were 89.6% and 94.1%.	15	Enzyme-Linked Immunosorbent Assay (ELISA)	1.6 × 10(−7) M	Detection	SELEX	Biotinylated	N/A	N/A	N/A	N/A	N/A