Target : Biofilm

Total records found: 16

Download:

Search:

AptBacDB_ID ⇅	PMID/DOI ⇅	Year ⇅	Title ⇅	Aptamer name ⇅	Sequence (5′ to 3′) ⇅	Length ⇅	Library ⇅	Type ⇅	Target Organism ⇅	Target ⇅	Objective/Mechanism ⇅	Outcome/Inhibitory effect ⇅	No. of selection round SELEX ⇅	Determination of affinity method ⇅	Kd value ⇅	Activity Role ⇅	Method ⇅	Modification ⇅	Cytotoxicity (cell viability) ⇅	Stability⇅	Potential Candidate ⇅	Half-life ⇅	Patent ⇅
ABdb_0834	28937998	2017	Selection of DNA aptamers specific for live Pseudomonas aeruginosa	JN08	ATGAGAGCGTCGGTGTGGTAACTTAATCCTCTAGTTTTAATTCTAGATACGGCGCATGCACTCTATGTAGGAGGGTGCGGAAGTA	85	5'-ATGAGAGCGTCGGTGTGGTA-N45-TACTTCCGCACCCTCCTACA-3'	ssDNA	Pseudomonas Aeruginosa 692 (PA692) (ATCC 14502)	Whole live and biofilm derived PA692 P. aeruginosa cells	Identify aptamers to P. aeruginosa grown as biofilms in microfluidic cells.	All aptamers were selective for P. aeruginosa with minimal cross-reactivity.	7	Flow Cytometry	54.9 ± 7.8 nM	Detection	Whole Cell-SELEX	N/A	Aptamers had no intrinsic bacteriostatic and/or bactericidal activity.	N/A	N/A	N/A	N/A
ABdb_0835	28937998	2017	Selection of DNA aptamers specific for live Pseudomonas aeruginosa	JN27	ATGAGAGCGTCGGTGTGGTAACTAGTCTGATTTCTATTTCCTTTAATTAGTCTGCACACATTGCATTGTAGGAGGGTGCGGAAGTA	86	5'-ATGAGAGCGTCGGTGTGGTA-N45-TACTTCCGCACCCTCCTACA-3'	ssDNA	Pseudomonas Aeruginosa 692 (PA692) (ATCC 14502)	Whole live and biofilm derived PA692 P. aeruginosa cells	Identify aptamers to P. aeruginosa grown as biofilms in microfluidic cells.	All aptamers were selective for P. aeruginosa with minimal cross-reactivity.	7	Flow Cytometry	28.5 ± 4.9 nM	Detection	Whole Cell-SELEX	N/A	Aptamers had no intrinsic bacteriostatic and/or bactericidal activity.	N/A	N/A	N/A	N/A
ABdb_0836	28937998	2017	Selection of DNA aptamers specific for live Pseudomonas aeruginosa	JN27.SH	TAATTAGTCTGCACACATTGCATTGTAGGAGGGTGCGGAAGTA	43	5'-ATGAGAGCGTCGGTGTGGTA-N45-TACTTCCGCACCCTCCTACA-3'	ssDNA	Pseudomonas Aeruginosa 692 (PA692) (ATCC 14502)	Whole live and biofilm derived PA692 P. aeruginosa cells	Identify aptamers to P. aeruginosa grown as biofilms in microfluidic cells.	All aptamers were selective for P. aeruginosa with minimal cross-reactivity.	7	Flow Cytometry	26.9 ± 5.6 nM	Detection	Whole Cell-SELEX	N/A	Aptamers had no intrinsic bacteriostatic and/or bactericidal activity.	N/A	N/A	N/A	N/A
ABdb_0837	28937998	2017	Selection of DNA aptamers specific for live Pseudomonas aeruginosa	JN08.SH	ATGCACTCTATGTAGGAGGGTGCGGA	26	5'-ATGAGAGCGTCGGTGTGGTA-N45-TACTTCCGCACCCTCCTACA-3'	ssDNA	Pseudomonas Aeruginosa 692 (PA692) (ATCC 14502)	Whole live and biofilm derived PA692 P. aeruginosa cells	Identify aptamers to P. aeruginosa grown as biofilms in microfluidic cells.	All aptamers were selective for P. aeruginosa with minimal cross-reactivity.	7	Flow Cytometry	52.9 ± 10.4 nM	Detection	Whole Cell-SELEX	N/A	Aptamers had no intrinsic bacteriostatic and/or bactericidal activity.	N/A	N/A	N/A	N/A
ABdb_0838	28937998	2017	Selection of DNA aptamers specific for live Pseudomonas aeruginosa	JN17.SH	ATCCTCCTATCTATCGGTAGTTGTAGGAGGGTGCGG	36	5'-ATGAGAGCGTCGGTGTGGTA-N45-TACTTCCGCACCCTCCTACA-3'	ssDNA	Pseudomonas Aeruginosa 692 (PA692) (ATCC 14502)	Whole live and biofilm derived PA692 P. aeruginosa cells	Identify aptamers to P. aeruginosa grown as biofilms in microfluidic cells.	All aptamers were selective for P. aeruginosa with minimal cross-reactivity.	7	Flow Cytometry	29 ± 7.3 nM	Detection	Whole Cell-SELEX	N/A	Aptamers had no intrinsic bacteriostatic and/or bactericidal activity.	N/A	N/A	N/A	N/A
ABdb_0839	28937998	2017	Selection of DNA aptamers specific for live Pseudomonas aeruginosa	JN21.SH	AGAGCGTCGGTGTGGTAACTGTTCAGGAGGATGACATTGTCGCCT	45	5'-ATGAGAGCGTCGGTGTGGTA-N45-TACTTCCGCACCCTCCTACA-3'	ssDNA	Pseudomonas Aeruginosa 692 (PA692) (ATCC 14502)	Whole live and biofilm derived PA692 P. aeruginosa cells	Identify aptamers to P. aeruginosa grown as biofilms in microfluidic cells.	All aptamers were selective for P. aeruginosa with minimal cross-reactivity.	7	Flow Cytometry	18.1 ± 3.4 nM	Detection	Whole Cell-SELEX	N/A	Aptamers had no intrinsic bacteriostatic and/or bactericidal activity.	N/A	N/A	N/A	N/A
ABdb_0840	28937998	2017	Selection of DNA aptamers specific for live Pseudomonas aeruginosa	St17Lp21	ATCCTCCTAGGTAACTGTTCAGGATGTAGGAGGGT	35	5'-ATGAGAGCGTCGGTGTGGTA-N45-TACTTCCGCACCCTCCTACA-3'	ssDNA	Pseudomonas Aeruginosa 692 (PA692) (ATCC 14502)	Whole live and biofilm derived PA692 P. aeruginosa cells	Identify aptamers to P. aeruginosa grown as biofilms in microfluidic cells.	All aptamers were selective for P. aeruginosa with minimal cross-reactivity.	7	Flow Cytometry	16.9 ± 3.9 nM	Detection	Whole Cell-SELEX	N/A	Aptamers had no intrinsic bacteriostatic and/or bactericidal activity.	N/A	N/A	N/A	N/A
ABdb_0841	28937998	2017	Selection of DNA aptamers specific for live Pseudomonas aeruginosa	St21Lp17	AAGCGTCGGTGTTCTATCGGTAGTTGACACCGACGCCT	38	5'-ATGAGAGCGTCGGTGTGGTA-N45-TACTTCCGCACCCTCCTACA-3'	ssDNA	Pseudomonas Aeruginosa 692 (PA692) (ATCC 14502)	Whole live and biofilm derived PA692 P. aeruginosa cells	Identify aptamers to P. aeruginosa grown as biofilms in microfluidic cells.	All aptamers were selective for P. aeruginosa with minimal cross-reactivity.	7	Flow Cytometry	13.5 ± 2 nM	Detection	Whole Cell-SELEX	N/A	Aptamers had no intrinsic bacteriostatic and/or bactericidal activity.	N/A	N/A	N/A	N/A
ABdb_0842	28937998	2017	Selection of DNA aptamers specific for live Pseudomonas aeruginosa	St08Lp17	ATGCACTCTTCTATCGGTAGTTGAGGGTGCGG	32	5'-ATGAGAGCGTCGGTGTGGTA-N45-TACTTCCGCACCCTCCTACA-3'	ssDNA	Pseudomonas Aeruginosa 692 (PA692) (ATCC 14502)	Whole live and biofilm derived PA692 P. aeruginosa cells	Identify aptamers to P. aeruginosa grown as biofilms in microfluidic cells.	All aptamers were selective for P. aeruginosa with minimal cross-reactivity.	7	Flow Cytometry	12.5 ± 2.4 nM	Detection	Whole Cell-SELEX	N/A	Aptamers had no intrinsic bacteriostatic and/or bactericidal activity.	N/A	N/A	N/A	N/A
ABdb_1002	29357405	2018	Combat biofilm by bacteriostatic aptamer-functionalized graphene oxide	ST-3 (or ST-33)	CTCCTCTGACTGTAACCACGGTGGGAGAGATGCTATACAATCTTGTAAGGCGATGGACCG	60	N/A	ssDNA	Salmonella Typhimurium (S. Typhimurium)	Biofilm	Aptamer-GO conjugate reduces the cellular membrane potential to inhibit biofilm formation.	93.3 ± 3.4% inhibition ratio at the initial stage of biofilm formation and 84.6 ± 5.1% degradation ratio on formed biofilms.	12	N/A	N/A	Therapeutics	N/A	5'-Amidation (NH₂)	N/A	N/A	N/A	N/A	N/A
ABdb_1376	32785202	2020	Spectroscopic Study on Pseudomonas Aeruginosa Biofilm in the Presence of the Aptamer-DNA Scaffolded Silver Nanoclusters	NC1	TACTTCCGCACCCTCCTACA	20	N/A	ssDNA	Pseudomonas Aeruginosa (ATCC 10145)	Biofilm	DNA aptamer-enclosed silver nanoclusters (Ag-NC) were used to prevent biofilms.	Potency of an aptamer-DNA enclosed Ag-NC with a decrease in the net Ld wrt control follows NC2 > NC1 > NC5 > positive control ≈ NC3 > NC6.	N/A	N/A	N/A	Therapeutics	N/A	N/A	N/A	N/A	N/A	N/A	N/A
ABdb_1377	32785202	2020	Spectroscopic Study on Pseudomonas Aeruginosa Biofilm in the Presence of the Aptamer-DNA Scaffolded Silver Nanoclusters	NC2	CCCCCGTTGCTTTCGCTTTTCCTTTCGCTTTTGTTCGTTTCGTCCCTGCTTCCTTTCTTG	60	N/A	ssDNA	Pseudomonas Aeruginosa (ATCC 10145)	Biofilm	DNA aptamer-enclosed silver nanoclusters (Ag-NC) were used to prevent biofilms.	Potency of an aptamer-DNA enclosed Ag-NC with a decrease in the net Ld wrt control follows NC2 > NC1 > NC5 > positive control ≈ NC3 > NC6.	N/A	N/A	N/A	Therapeutics	N/A	N/A	N/A	N/A	N/A	N/A	N/A
ABdb_1378	32785202	2020	Spectroscopic Study on Pseudomonas Aeruginosa Biofilm in the Presence of the Aptamer-DNA Scaffolded Silver Nanoclusters	NC3	CCCTTTCCCTTTCCCATTCCCGTTCCCTTTCCCTTTCCCATTCCCGTTA	49	N/A	ssDNA	Pseudomonas Aeruginosa (ATCC 10145)	Biofilm	DNA aptamer-enclosed silver nanoclusters (Ag-NC) were used to prevent biofilms.	Potency of an aptamer-DNA enclosed Ag-NC with a decrease in the net Ld wrt control follows NC2 > NC1 > NC5 > positive control ≈ NC3 > NC6.	N/A	N/A	N/A	Therapeutics	N/A	N/A	N/A	N/A	N/A	N/A	N/A
ABdb_1379	32785202	2020	Spectroscopic Study on Pseudomonas Aeruginosa Biofilm in the Presence of the Aptamer-DNA Scaffolded Silver Nanoclusters	NC5	ATGAGAGCGTCGGTGTGGTA-CCCTTTCCCTTTCCCATTCCCGTTCCCTTTCCCTTTCCCATTCCCGTTA-TACTTCCGCACCCTCCTACA	89	N/A	ssDNA	Pseudomonas Aeruginosa (ATCC 10145)	Biofilm	DNA aptamer-enclosed silver nanoclusters (Ag-NC) were used to prevent biofilms.	Potency of an aptamer-DNA enclosed Ag-NC with a decrease in the net Ld wrt control follows NC2 > NC1 > NC5 > positive control ≈ NC3 > NC6.	N/A	N/A	N/A	Therapeutics	N/A	N/A	N/A	N/A	N/A	N/A	N/A
ABdb_1380	32785202	2020	Spectroscopic Study on Pseudomonas Aeruginosa Biofilm in the Presence of the Aptamer-DNA Scaffolded Silver Nanoclusters	NC6	ATGAGAGCGTCGGTGTGGTA	20	N/A	ssDNA	Pseudomonas Aeruginosa (ATCC 10145)	Biofilm	DNA aptamer-enclosed silver nanoclusters (Ag-NC) were used to prevent biofilms.	Potency of an aptamer-DNA enclosed Ag-NC with a decrease in the net Ld wrt control follows NC2 > NC1 > NC5 > positive control ≈ NC3 > NC6.	N/A	N/A	N/A	Therapeutics	N/A	N/A	N/A	N/A	N/A	N/A	N/A
ABdb_1829	37429429	2024	Assessment of the growth inhibition and anti-biofilm activity of aptamer (PmA2G02) against Proteus mirabilis 1429T	PmA2G02	ATTACTTACGCTATCTAAttttGCTGTAGGGGAGGAGGGTGGGTtttTTATCATCTGGTATGTTA	65	N/A	ssDNA	Proteus Mirabilis (1429T)	Biofilm	Inhibit biofilm formation, adhesion, and mobility, along with a reduction in biofilm-related genes, namely rsbA, fliC2 & fimD, in P. mirabilis.	Aptamer treatment resulted in a 50% reduction in biofilm thickness and a 2.29-fold and 1.34-fold decrease in mRNA expression of the fliC2 and fimD genes, respectively.	N/A	N/A	N/A	Therapeutics	Whole Cell-SELEX	N/A	Aptamer treatment did not significantly affect cell viability.	N/A	N/A	N/A	N/A