Target : A85C (Rv0129c gene)

Total records found: 10

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AptBacDB_ID ⇅	PMID/DOI ⇅	Year ⇅	Title ⇅	Aptamer name ⇅	Sequence (5′ to 3′) ⇅	Length ⇅	Library ⇅	Type ⇅	Target Organism ⇅	Target ⇅	Objective/Mechanism ⇅	Outcome/Inhibitory effect ⇅	No. of selection round SELEX ⇅	Determination of affinity method ⇅	Kd value ⇅	Activity Role ⇅	Method ⇅	Modification ⇅	Cytotoxicity (cell viability) ⇅	Stability⇅	Potential Candidate ⇅	Half-life ⇅	Patent ⇅
ABdb_2039	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	4950-27	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85C (Rv0129c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	Exhibit LOD of 0.36 pM, 1.80 pM, 0.61 pM and 3.4 × 10(8) cells/ml in Buffer, Normal serum(40%), Urine protein (100 μg) and serum bacterial load, respectively.	N/A	Radiolabel Equilibration Binding Assay	0.03 nM	Biosensor	N/A	NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	Best Candidate	N/A	N/A
ABdb_2040	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	4955-49	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85C (Rv0129c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	N/A	N/A	Radiolabel Equilibration Binding Assay	0.26 nM	Biosensor	N/A	TrpdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	N/A	N/A	N/A
ABdb_2041	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	5569-2	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85C (Rv0129c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	Exhibit LOD of 0.23 pM, 0.28 pM, 0.36 pM and 2.6 × 10(7) cells/ml in Buffer, Normal serum(40%), Urine protein (100 μg) and serum bacterial load, respectively.	N/A	Radiolabel Equilibration Binding Assay	0.01 nM	Biosensor	N/A	2NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	Best Candidate	N/A	N/A
ABdb_2042	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	5575-1	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85C (Rv0129c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	N/A	N/A	Radiolabel Equilibration Binding Assay	0.03 nM	Biosensor	N/A	PEdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	N/A	N/A	N/A
ABdb_2043	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	12075-16	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85C (Rv0129c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	Exhibit LOD of 7.39 pM, 5.38 pM, 8.51 pM and 4.9 × 10(8) cells/ml in Buffer, Normal serum(40%), Urine protein (100 μg) and serum bacterial load, respectively.	N/A	Radiolabel Equilibration Binding Assay	0.05 nM	Biosensor	N/A	NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	Best Candidate	N/A	N/A
ABdb_2044	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	12075-40	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85C (Rv0129c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	N/A	N/A	Radiolabel Equilibration Binding Assay	0.13 nM	Biosensor	N/A	NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	N/A	N/A	N/A
ABdb_2045	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	14494-53	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85C (Rv0129c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	N/A	N/A	Radiolabel Equilibration Binding Assay	0.03 nM	Biosensor	N/A	2NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	N/A	N/A	N/A
ABdb_2046	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	14494-124	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85C (Rv0129c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	Exhibit LOD of 0.14 pM, 0.07 pM, 0.06 pM and 2.7 × 10(7) cells/ml in Buffer, Normal serum(40%), Urine protein (100 μg) and serum bacterial load, respectively.	N/A	Radiolabel Equilibration Binding Assay	0.02 nM	Biosensor	N/A	2NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	Best Candidate	N/A	N/A
ABdb_2047	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	14506-48	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85C (Rv0129c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	Exhibit LOD of 0.89 pM, 1.98 pM, 2.10 pM and 3.3 × 10(8) cells/ml in Buffer, Normal serum(40%), Urine protein (100 μg) and serum bacterial load, respectively.	N/A	Radiolabel Equilibration Binding Assay	0.04 nM	Biosensor	N/A	PPdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	Best Candidate	N/A	N/A
ABdb_2048	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	14506-76	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85C (Rv0129c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	N/A	N/A	Radiolabel Equilibration Binding Assay	0.03 nM	Biosensor	N/A	PPdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	N/A	N/A	N/A