Target : A85B (Rv1886c gene)

Total records found: 8

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AptBacDB_ID ⇅	PMID/DOI ⇅	Year ⇅	Title ⇅	Aptamer name ⇅	Sequence (5′ to 3′) ⇅	Length ⇅	Library ⇅	Type ⇅	Target Organism ⇅	Target ⇅	Objective/Mechanism ⇅	Outcome/Inhibitory effect ⇅	No. of selection round SELEX ⇅	Determination of affinity method ⇅	Kd value ⇅	Activity Role ⇅	Method ⇅	Modification ⇅	Cytotoxicity (cell viability) ⇅	Stability⇅	Potential Candidate ⇅	Half-life ⇅	Patent ⇅
ABdb_2031	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	4949-52	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85B (Rv1886c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	N/A	N/A	Radiolabel Equilibration Binding Assay	6.39 nM	Biosensor	N/A	NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	N/A	N/A	N/A
ABdb_2032	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	4954-5	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85B (Rv1886c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	N/A	N/A	Radiolabel Equilibration Binding Assay	0.31 nM	Biosensor	N/A	TrpdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	N/A	N/A	N/A
ABdb_2033	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	12074-5	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85B (Rv1886c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	Exhibit LOD of 0.27 pM, 0.18 pM, 0.30 pM and 5.5 × 10(5) cells/ml in Buffer, Normal serum(40%), Urine protein (100 μg) and serum bacterial load, respectively.	N/A	Radiolabel Equilibration Binding Assay	0.08 nM	Biosensor	N/A	NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	Best Candidate	N/A	N/A
ABdb_2034	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	12074-11	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85B (Rv1886c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	Exhibit LOD of 0.36 pM, 0.72 pM, 0.18 pM and 1.8 × 10(6) cells/ml in Buffer, Normal serum(40%), Urine protein (100 μg) and serum bacterial load, respectively.	N/A	Radiolabel Equilibration Binding Assay	0.14 nM	Biosensor	N/A	NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	Best Candidate	N/A	N/A
ABdb_2035	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	12093-26	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85B (Rv1886c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	N/A	N/A	Radiolabel Equilibration Binding Assay	0.26 nM	Biosensor	N/A	TrpdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	N/A	N/A	N/A
ABdb_2036	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	14493-5	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85B (Rv1886c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	N/A	N/A	Radiolabel Equilibration Binding Assay	1.94 nM	Biosensor	N/A	2NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	N/A	N/A	N/A
ABdb_2037	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	14493-16	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85B (Rv1886c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	N/A	N/A	Radiolabel Equilibration Binding Assay	0.29 nM	Biosensor	N/A	2NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	N/A	N/A	N/A
ABdb_2038	28794178	2017	Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications	14505-57	N/A	N/A	N/A	ssDNA	Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources)	A85B (Rv1886c gene)	Slow-off-rate modified aptamer (SOMAmer) for detecting TB.	Exhibit LOD of 4.15 pM, 5.13 pM, 55.47 pM and 4 × 10(7) cells/ml in Buffer, Normal serum(40%), Urine protein (100 μg) and serum bacterial load, respectively.	N/A	Radiolabel Equilibration Binding Assay	0.13 nM	Biosensor	N/A	PPdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT)	N/A	N/A	Best Candidate	N/A	N/A