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| AptBacDB_ID ⇅ | PMID/DOI ⇅ | Year ⇅ | Title ⇅ | Aptamer name ⇅ | Sequence (5′ to 3′) ⇅ | Length ⇅ | Library ⇅ | Type ⇅ | Target Organism ⇅ | Target ⇅ | Objective/Mechanism ⇅ | Outcome/Inhibitory effect ⇅ | No. of selection round SELEX ⇅ | Determination of affinity method ⇅ | Kd value ⇅ | Activity Role ⇅ | Method ⇅ | Modification ⇅ | Cytotoxicity (cell viability) ⇅ | Stability⇅ | Potential Candidate ⇅ | Half-life ⇅ | Patent ⇅ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ABdb_2023 | 28794178 | 2017 | Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications | 4948-1 | N/A | N/A | N/A | ssDNA | Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources) | A85A (Rv3804c gene) | Slow-off-rate modified aptamer (SOMAmer) for detecting TB. | N/A | N/A | Radiolabel Equilibration Binding Assay | 0.05 nM | Biosensor | N/A | NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) | N/A | N/A | N/A | N/A | N/A |
| ABdb_2024 | 28794178 | 2017 | Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications | 4953-64 | N/A | N/A | N/A | ssDNA | Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources) | A85A (Rv3804c gene) | Slow-off-rate modified aptamer (SOMAmer) for detecting TB. | N/A | N/A | Radiolabel Equilibration Binding Assay | 0.06 nM | Biosensor | N/A | TrpdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) | N/A | N/A | N/A | N/A | N/A |
| ABdb_2025 | 28794178 | 2017 | Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications | 12073-8 | N/A | N/A | N/A | ssDNA | Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources) | A85A (Rv3804c gene) | Slow-off-rate modified aptamer (SOMAmer) for detecting TB. | N/A | N/A | Radiolabel Equilibration Binding Assay | 0.09 nM | Biosensor | N/A | NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) | N/A | N/A | N/A | N/A | N/A |
| ABdb_2026 | 28794178 | 2017 | Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications | 12073-32 | N/A | N/A | N/A | ssDNA | Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources) | A85A (Rv3804c gene) | Slow-off-rate modified aptamer (SOMAmer) for detecting TB. | N/A | N/A | Radiolabel Equilibration Binding Assay | 0.16 nM | Biosensor | N/A | NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) | N/A | N/A | N/A | N/A | N/A |
| ABdb_2027 | 28794178 | 2017 | Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications | 12092-7 | N/A | N/A | N/A | ssDNA | Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources) | A85A (Rv3804c gene) | Slow-off-rate modified aptamer (SOMAmer) for detecting TB. | N/A | N/A | Radiolabel Equilibration Binding Assay | 0.06 nM | Biosensor | N/A | TrpdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) | N/A | N/A | N/A | N/A | N/A |
| ABdb_2028 | 28794178 | 2017 | Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications | 14492-7 | N/A | N/A | N/A | ssDNA | Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources) | A85A (Rv3804c gene) | Slow-off-rate modified aptamer (SOMAmer) for detecting TB. | N/A | N/A | Radiolabel Equilibration Binding Assay | 0.24 nM | Biosensor | N/A | 2NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) | N/A | N/A | N/A | N/A | N/A |
| ABdb_2029 | 28794178 | 2017 | Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications | 14492-11 | N/A | N/A | N/A | ssDNA | Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources) | A85A (Rv3804c gene) | Slow-off-rate modified aptamer (SOMAmer) for detecting TB. | N/A | N/A | Radiolabel Equilibration Binding Assay | 0.21 nM | Biosensor | N/A | 2NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) | N/A | N/A | N/A | N/A | N/A |
| ABdb_2030 | 28794178 | 2017 | Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications | 14504-6 | N/A | N/A | N/A | ssDNA | Mycobacterium Tuberculosis (H37Rv) (NR-14865; BEI Resources) | A85A (Rv3804c gene) | Slow-off-rate modified aptamer (SOMAmer) for detecting TB. | Exhibit LOD of 0.29 pM, 0.97 pM, 0.92 pM and 7.3 × 10(6) cells/ml in Buffer, Normal serum(40%), Urine protein (100 μg) and serum bacterial load, respectively. | N/A | Radiolabel Equilibration Binding Assay | 0.07 nM | Biosensor | N/A | PPdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) | N/A | N/A | Best Candidate | N/A | N/A |