AptBacterialDB

Activity Role : Therapeutics/Immunmodulatory

Total records found: 27

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AptBacDB_ID ⇅ PMID/DOI ⇅ Year ⇅ Title ⇅ Aptamer name ⇅ Sequence (5′ to 3′) ⇅ Length ⇅ Library ⇅ Type ⇅ Target Organism ⇅ Target ⇅ Objective/Mechanism ⇅ Outcome/Inhibitory effect ⇅ No. of selection round SELEX ⇅ Determination of affinity method ⇅ Kd value ⇅ Activity Role ⇅ Method ⇅ Modification ⇅ Cytotoxicity (cell viability) ⇅ Stability⇅ Potential Candidate ⇅ Half-life ⇅ Patent ⇅
ABdb_0343 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL1GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-GGCGCCATAGCGACGGGGCCATTCCAAGAA-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).ZXL1 bound to virulent M. tb H37Rv much more strongly (52.2%) than to the other Mycobacteria strains tested, M. smegmatis (2.5%) and BCG (13.9%). LPS-stimulated human DC groups showed that ZXL1 decreased IL-10 production by 31–36% and increased IL-12 production by 52–91%, thereby reducing the progression of infection and bacterial loads in mice and rhesus monkeys.12Enzyme-Linked Oligonucleotide Assay (ELONA)436.3 ± 37.84 nMTherapeutics/ImmunmodulatorySELEXBiotinylated or FAM LabeledZXL1 showed no significant cytotoxicity at concentrations ranging from 2 to 15 microM at the 168-hour test.N/ABest CandidateN/AN/A
ABdb_0344 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL2GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-AGTCCACGATAATCACACACACGGACACCC-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0345 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL4GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-CACGCCCAATAGTGGCTCCAGCTCATCTCT-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0346 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL5GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-CATCGATGTACCCTACCTACATGTTACGTT-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0347 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL6GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-ACCTACAGCGACACCTAACTGAGTAGAACT-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0348 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL7GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-TACCTAACACTTCCTGCTCCACCTTTATTA-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0349 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL8GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-CCCTGATTCCCCCTCATCCGATGGACATCT-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0350 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL9GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-GACCCTCATGATACCAACCACTCCAGTCAA-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0351 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL10GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-TATCCCAGTGGCATTAACTACCCACTCGCA-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0352 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL3GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-TCACGGAGTGAGGGGCTGTTCATTAAGAGA-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0353 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL12GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-TCGCCTGATAGGTCTGTGATCCAATCCAAT-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0354 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL13GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-TCTGCTTGCCGCTGATCCGCCAATTCGATC-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0355 245722952014Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeysZXL14GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-TCGTGCCGACGCTGCCGAATAGCACTGCAC-GGGTCAATGCGTCATA885'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N30-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentify aptamers that bind to and inhibit ManLAM recognition by host cells and ManLAM-induced immunosuppression of CD11c+ dendritic cells (DCs).N/A12Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0538 256243252015Neutralization of staphylococcal enterotoxin B by an aptamer antagonistA11ATACCAGCTTATTCAATT-TAGGCGGTGGAGATAGTAAGTGCAATCTAGGCGGTGGAGATAGTAAGTGCAATCTATGCC-AGATAGTAAGTGCAATCT965'-ATACCAGCTTATTCAATT-N60-AGATAGTAAGTGCAATCT3'ssDNAStaphylococcus aureus (S. aureus)Staphylococcal Enterotoxin B (SEB)Identify aptamers that bind to and block SEB-mediated toxic shock (TSS) in vitro.Inhibited SEB-mediated PBMC proliferation of 93% and TNF-α, IL-1β, IL-6, IL-2, and IFN-γ in culture supernatants were reduced by 77, 97, 64, 96, and 99%, respectively. 90% survival of mouse models of SEB-induced TSS.11Fluorescence Spectroscopy64 nMTherapeutics/ImmunmodulatorySELEX5′-Polyethylene glycol (PEG) with 5'-Amidation (NH₂) and 3’-Inverted Thymidine (3'-idT) and 5'-Biotinylated or 5'-FITC LabeledShowed no cytotoxic effects on PBMCs.N/AN/AN/AN/A
ABdb_0539 256243252015Neutralization of staphylococcal enterotoxin B by an aptamer antagonistA2ATACCAGCTTATTCAATT-GATCGATCGATCAGTCAGTCGACCAACGCACGACACGCATCGCTCTATCTCGTCGAACAG-AGATAGTAAGTGCAATCT965'-ATACCAGCTTATTCAATT-N60-AGATAGTAAGTGCAATCT3'ssDNAStaphylococcus aureus (S. aureus)Staphylococcal Enterotoxin B (SEB)Identify aptamers that bind to and block SEB-mediated toxic shock (TSS) in vitro.A2 achieved 34% PBMC proliferation inhibition.11Fluorescence Spectroscopy26 nMTherapeutics/ImmunmodulatorySELEX5'-Biotinylated and 5'-FITC LabeledN/AN/ABest CandidateN/AN/A
ABdb_0753 275295082016A Single ssDNA Aptamer Binding to Mannose-Capped Lipoarabinomannan of Bacillus Calmette-Guérin Enhances Immunoprotective Effect against TuberculosisBM2GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-CCCCATGAACTAGGCTCCACAATGAGTTTGG-GGGTCAATGCGTCATA895'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N31-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Bovis (bacillus Calmette–Guérin (BCG))Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentified aptamers against ManLAM and served as an immune enhancer for BCG against M. tb H37Rv infection via blocking MR binding, triggering ManLAM–CD44 signalling, and enhancing M1 macrophage and Th1 activation via cellular surface CD44 in vitro and in vivo.Ki of BM2 was estimated to be 10.34 ± 0.27 nM, with a LOD of 1 × 10^4 cfu/100 μL of BCG.10Enzyme-Linked Oligonucleotide Assay (ELONA)8.59 ± 1.23 nMTherapeutics/ImmunmodulatorySELEXBiotinylatedBM2 was demonstrated to be safe with low toxicity based on in vitro and in vivo toxicity analyses.BM2–BCG complex could be detected and remained stable for at least 30 days in vivo.N/AN/AN/A
ABdb_0754 275295082016A Single ssDNA Aptamer Binding to Mannose-Capped Lipoarabinomannan of Bacillus Calmette-Guérin Enhances Immunoprotective Effect against TuberculosisBM1GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-CGGTCGTAGACCGGGAGTTGTTGTTAGTTCA-GGGTCAATGCGTCATA895'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N31-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Bovis (bacillus Calmette–Guérin (BCG))Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentified aptamers against ManLAM and served as an immune enhancer for BCG against M. tb H37Rv infection via blocking MR binding, triggering ManLAM–CD44 signalling, and enhancing M1 macrophage and Th1 activation via cellular surface CD44 in vitro and in vivo.N/A10Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/ABest CandidateN/AN/A
ABdb_0755 275295082016A Single ssDNA Aptamer Binding to Mannose-Capped Lipoarabinomannan of Bacillus Calmette-Guérin Enhances Immunoprotective Effect against TuberculosisBM4GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-CGCGCAGCGGGTCGACTTCATTCCTCACCAT-GGGTCAATGCGTCATA895'-GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-N31-GGGTCAATGCGTCATA-3'ssDNAMycobacterium Bovis (bacillus Calmette–Guérin (BCG))Mannose-capped lipoarabinomannan (ManLAM) epitopeIdentified aptamers against ManLAM and served as an immune enhancer for BCG against M. tb H37Rv infection via blocking MR binding, triggering ManLAM–CD44 signalling, and enhancing M1 macrophage and Th1 activation via cellular surface CD44 in vitro and in vivo.N/A10Enzyme-Linked Oligonucleotide Assay (ELONA)N/ATherapeutics/ImmunmodulatorySELEXBiotinylatedN/AN/AN/AN/AN/A
ABdb_0756 271794222016Inhibition of the superantigenic activities of Staphylococcal enterotoxin A by an aptamer antagonistS3ATACCAGCTTATTCAATT-CCCGCCTCTGAGCATTATTAATGTTATACCTTACGGCTGG-AGATAGTAAGTGCAATCT765'-ATACCAGCTTATTCAATT-N40-AGATAGTAAGTGCAATCT-3'ssDNAStaphylococcus aureus (S. aureus)Staphylococcal Enterotoxin A (SEA)Identify aptamers that bind to and block superantigen activity of SEA.Inhibited PBMCs proliferation with an inhibition rate of 84% and reduced IFN-γ, TNF-α, IL-2, and IL-6 secretions by 89%, 87%, 73%, 69%, respectively. PEGS3 allowed 79% of the mice to survive the lethal challenge.9Enzyme-Linked Aptamer Assay (ELAA)36.93 ± 7.29 nMTherapeutics/ImmunmodulatorySELEX5′-Polyethylene glycol (PEG) with 5'-Amidation (NH₂) and 3’-Inverted Thymidine (3'-idT) and 5'-Biotinylated or 5'-FAM LabeledN/AN/AN/AN/AN/A
ABdb_0757 271794222016Inhibition of the superantigenic activities of Staphylococcal enterotoxin A by an aptamer antagonistS6ATACCAGCTTATTCAATT-GCCGCGGAATTGTGGCTTGGTGTCGTGGTCAGGGGCTGG-AGATAGTAAGTGCAATCT755'-ATACCAGCTTATTCAATT-N40-AGATAGTAAGTGCAATCT-3'ssDNAStaphylococcus aureus (S. aureus)Staphylococcal Enterotoxin A (SEA)Identify aptamers that bind to and block superantigen activity of SEA.N/A9Enzyme-Linked Aptamer Assay (ELAA)N/ATherapeutics/ImmunmodulatorySELEX5'-Biotinylated and 5'-FAM LabeledN/AN/ABest CandidateN/AN/A
ABdb_0758 271794222016Inhibition of the superantigenic activities of Staphylococcal enterotoxin A by an aptamer antagonistS12ATACCAGCTTATTCAATT-GCCACTGTGGACTTGTTATTCGTCTTTGCCGTCTAATTCG-AGATAGTAAGTGCAATCT765'-ATACCAGCTTATTCAATT-N40-AGATAGTAAGTGCAATCT-3'ssDNAStaphylococcus aureus (S. aureus)Staphylococcal Enterotoxin A (SEA)Identify aptamers that bind to and block superantigen activity of SEA.Inhibited PBMCs proliferation with an inhibition rate of 84%.9Enzyme-Linked Aptamer Assay (ELAA)79.35 ± 12.09 nMTherapeutics/ImmunmodulatorySELEX5'-Biotinylated and 5'-FAM LabeledN/AN/AN/AN/AN/A
ABdb_0759 271794222016Inhibition of the superantigenic activities of Staphylococcal enterotoxin A by an aptamer antagonistS23ATACCAGCTTATTCAATT-GCAACAATGTTGTGTCAGCAAGTTGGTTGGCGGTGTATTG-AGATAGTAAGTGCAATCT765'-ATACCAGCTTATTCAATT-N40-AGATAGTAAGTGCAATCT-3'ssDNAStaphylococcus aureus (S. aureus)Staphylococcal Enterotoxin A (SEA)Identify aptamers that bind to and block superantigen activity of SEA.N/A9Enzyme-Linked Aptamer Assay (ELAA)N/ATherapeutics/ImmunmodulatorySELEX5'-Biotinylated and 5'-FAM LabeledN/AN/AN/AN/AN/A
ABdb_0832 282066802017A single-stranded DNA aptamer against mannose-capped lipoarabinomannan enhances anti-tuberculosis activity of macrophages through downregulation of lipid-sensing nuclear receptor peroxisome proliferator-activated receptor γ expressionZXL1GCGGAATTCTAATACGACTCACTATAGGGAACAGTCCGAGCC-GGCGCCATAGCGACGGGGCCATTCCAAGAA-GGGTCAATGCGTCATA88N/AssDNAMycobacterium Tuberculosis (H37Rv) (ATCC 93009)Mannose-capped lipoarabinomannan (ManLAM) epitopeDownregulate PPARγ expression by blocking the binding of ManLAM to MR on macrophages, and ZXL1 enhances IL-1β and IL-12 mRNA expression and cytokine production in ManLAM-treated macrophages but decreases IL-10 production.The percentage of macrophages that took up iH37Rv decreased from 15.9% to 7.2%, thereby inhibiting ManLAM-induced immunosuppression of DCs.N/AN/AN/ATherapeutics/ImmunmodulatoryN/ABiotinylatedN/AN/AN/AN/AN/A
ABdb_2012 244725392014DNA aptamers as a novel approach to neutralize Staphylococcus aureus α-toxinAT-27N/AN/A5'-ACCCCTGCAGGATCCTTTGCTGGTACC-N42-AGTATCGCTAATCAGTCTAGAGGGCCCCAGAAT-3'ssDNAStaphylococcus aureus (S. aureus)α-toxin (exotoxin)Identify aptamers that bind to and inhibit the cytotoxic activity of a-toxin and the upregulation of inflammatory cytokines TNF-a and IL-17.Increased the viability of α-toxin-treated Jurkat T cells to about 85–90%.10N/AN/ATherapeutics/ImmunmodulatorySELEX5'-BiotinylatedN/AN/AN/AN/AN/A
ABdb_2013 244725392014DNA aptamers as a novel approach to neutralize Staphylococcus aureus α-toxinAT-33N/AN/A5'-ACCCCTGCAGGATCCTTTGCTGGTACC-N42-AGTATCGCTAATCAGTCTAGAGGGCCCCAGAAT-3'ssDNAStaphylococcus aureus (S. aureus)α-toxin (exotoxin)Identify aptamers that bind to and inhibit the cytotoxic activity of a-toxin and the upregulation of inflammatory cytokines TNF-a and IL-17.AT-33 inhibited α-toxin-induced upregulation of TNF-α and IL-17 in Jurkat T cells. Increased the viability of α-toxin-treated Jurkat T cells to about 85–90%.10N/AN/ATherapeutics/ImmunmodulatorySELEX5'-BiotinylatedN/AN/AN/AN/AN/A
ABdb_2014 244725392014DNA aptamers as a novel approach to neutralize Staphylococcus aureus α-toxinAT-36N/AN/A5'-ACCCCTGCAGGATCCTTTGCTGGTACC-N42-AGTATCGCTAATCAGTCTAGAGGGCCCCAGAAT-3'ssDNAStaphylococcus aureus (S. aureus)α-toxin (exotoxin)Identify aptamers that bind to and inhibit the cytotoxic activity of a-toxin and the upregulation of inflammatory cytokines TNF-a and IL-17.AT-36 inhibited α-toxin-induced upregulation of TNF-α and IL-17 in Jurkat T cells. Increased the viability of α-toxin-treated Jurkat T cells to about 85–90%.10N/AN/ATherapeutics/ImmunmodulatorySELEX5'-BiotinylatedN/AN/AN/AN/AN/A
ABdb_2015 244725392014DNA aptamers as a novel approach to neutralize Staphylococcus aureus α-toxinAT-49N/AN/A5'-ACCCCTGCAGGATCCTTTGCTGGTACC-N42-AGTATCGCTAATCAGTCTAGAGGGCCCCAGAAT-3'ssDNAStaphylococcus aureus (S. aureus)α-toxin (exotoxin)Identify aptamers that bind to and inhibit the cytotoxic activity of a-toxin and the upregulation of inflammatory cytokines TNF-a and IL-17.Increased the viability of α-toxin-treated Jurkat T cells to about 85–90%.10N/AN/ATherapeutics/ImmunmodulatorySELEX5'-BiotinylatedN/AN/AN/AN/AN/A