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LLKKLLKK details |
Primary information | |
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ID | antitb_1230, |
Name | 24314557 |
N-Terminal modification | (LLKK)2 |
C-Terminal Modification | LLKKLLKK |
Chemical Modification | Free |
Linear/Cyclic | Free |
Length | None |
Chirality | Linear |
Nature | 8 |
Source | L |
Origin | Cationic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium smegmatis |
In Vitro/ In vivo | Mycobacterium smegmatis (ATCC No. 14468) |
Cell Line | MIC = 125 mg/L |
Inhibition Concentration | In vitro |
Sequence | 2014 |
Cytotoxicity | Rat red blood cells (rRBCs) |
In vivo Model | NA |
Lethal Dose | Very low, i.e. 50% hemolysis concentration (HC50) > 1000 mg/L |
Immune Responce | None |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | Membrane-lytic mechanism |
Other activities | Cell envelope |
PMID | None |
Year of Publication | Antibacterial |
Tertiary Structure (Technique) | Not Predicted), |
Primary information | |
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ID | antitb_1231, |
Name | 24314557 |
N-Terminal modification | (LLKK)2 |
C-Terminal Modification | LLKKLLKK |
Chemical Modification | Free |
Linear/Cyclic | Free |
Length | None |
Chirality | Linear |
Nature | 8 |
Source | L |
Origin | Cationic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium bovis |
In Vitro/ In vivo | Mycobacterium bovis BCG lux |
Cell Line | MIC = 500 mg/L |
Inhibition Concentration | In vitro |
Sequence | 2014 |
Cytotoxicity | Rat red blood cells (rRBCs) |
In vivo Model | NA |
Lethal Dose | Very low, i.e. 50% hemolysis concentration (HC50) > 1000 mg/L |
Immune Responce | None |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | Membrane-lytic mechanism |
Other activities | Cell envelope |
PMID | None |
Year of Publication | Antibacterial |
Tertiary Structure (Technique) | Not Predicted), |
Primary information | |
---|---|
ID | antitb_1232, |
Name | 24314557 |
N-Terminal modification | (LLKK)2 |
C-Terminal Modification | LLKKLLKK |
Chemical Modification | Free |
Linear/Cyclic | Free |
Length | None |
Chirality | Linear |
Nature | 8 |
Source | L |
Origin | Cationic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium tuberculosis |
In Vitro/ In vivo | Mycobacterium tuberculosis H37Rv |
Cell Line | MIC > 500 mg/L |
Inhibition Concentration | In vitro |
Sequence | 2014 |
Cytotoxicity | Rat red blood cells (rRBCs) |
In vivo Model | NA |
Lethal Dose | Very low, i.e. 50% hemolysis concentration (HC50) > 1000 mg/L |
Immune Responce | None |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | Membrane-lytic mechanism |
Other activities | Cell envelope |
PMID | None |
Year of Publication | Antibacterial |
Tertiary Structure (Technique) | Not Predicted), |
Primary information | |
---|---|
ID | antitb_1233, |
Name | 24314557 |
N-Terminal modification | (LLKK)2 |
C-Terminal Modification | LLKKLLKK |
Chemical Modification | Free |
Linear/Cyclic | Free |
Length | None |
Chirality | Linear |
Nature | 8 |
Source | L |
Origin | Cationic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium tuberculosis |
In Vitro/ In vivo | Mycobacterium tuberculosis CSU87 reistant to rifampicin, isoniazid, ethambutol, streptomycin and kanamycin |
Cell Line | MIC > 500 mg/L |
Inhibition Concentration | In vitro |
Sequence | 2014 |
Cytotoxicity | Rat red blood cells (rRBCs) |
In vivo Model | NA |
Lethal Dose | Very low, i.e. 50% hemolysis concentration (HC50) > 1000 mg/L |
Immune Responce | None |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | Membrane-lytic mechanism |
Other activities | Cell envelope |
PMID | None |
Year of Publication | Antibacterial |
Tertiary Structure (Technique) | Not Predicted), |
Primary information | |
---|---|
ID | antitb_1616, |
Name | 26380930 |
N-Terminal modification | LK |
C-Terminal Modification | LLKKLLKK |
Chemical Modification | Free |
Linear/Cyclic | Amidation |
Length | None |
Chirality | Linear |
Nature | 8 |
Source | L |
Origin | Cationic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium smegmatis |
In Vitro/ In vivo | Mycobacterium smegmatis ATCC14468 |
Cell Line | MIC = 125 μg/ml |
Inhibition Concentration | in vitro |
Sequence | 2015 |
Cytotoxicity | RAW 264.7 mouse macrophage |
In vivo Model | NA |
Lethal Dose | HC50= >500 μg/ml |
Immune Responce | NA |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | Bacterial membrane pore formation |
Other activities | NA |
PMID | NA |
Year of Publication | NA |
Tertiary Structure (Technique) | Not Predicted), |
Primary information | |
---|---|
ID | antitb_1622, |
Name | 26380930 |
N-Terminal modification | LK |
C-Terminal Modification | LLKKLLKK |
Chemical Modification | Free |
Linear/Cyclic | Amidation |
Length | None |
Chirality | Linear |
Nature | 8 |
Source | L |
Origin | Cationic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium smegmatis |
In Vitro/ In vivo | Mycobacterium smegmatis ATCC14468 |
Cell Line | MIC = 62.5 μg/ml |
Inhibition Concentration | in vitro |
Sequence | 2015 |
Cytotoxicity | RAW 264.7 mouse macrophage |
In vivo Model | NA |
Lethal Dose | HC50= >500 μg/ml |
Immune Responce | NA |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | Bacterial membrane pore formation |
Other activities | NA |
PMID | Peptide + Rifampicin (0.98 μg/ml) |
Year of Publication | NA |
Tertiary Structure (Technique) | Not Predicted), |