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KEFKRIVKRIKKFLRKLV details |
| Primary information | |
|---|---|
| ID | antitb_1395, |
| Name | 21790937 |
| N-Terminal modification | LLKKK-18 |
| C-Terminal Modification | KEFKRIVKRIKKFLRKLV |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 19 |
| Source | L |
| Origin | Cationic |
| Species | Natural |
| Strain | Murine macrophages |
| Inhibition Concentration | Mycobacteria smegmatis |
| In Vitro/ In vivo | M. smegmatis mc2 155 |
| Cell Line | MIC = 1μg /ml |
| Inhibition Concentration | in vitro |
| Sequence | 2011 |
| Cytotoxicity | J774.A1 macrophage cell lines |
| In vivo Model | 67% bacteria is cleared |
| Lethal Dose | NA |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1396, |
| Name | 21790937 |
| N-Terminal modification | LLKKK-18 |
| C-Terminal Modification | KEFKRIVKRIKKFLRKLV |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 19 |
| Source | L |
| Origin | Cationic |
| Species | Natural |
| Strain | Murine macrophages |
| Inhibition Concentration | Mycobacteria smegmatis |
| In Vitro/ In vivo | M. smegmatis mc2 155 |
| Cell Line | MIC = 1μg /ml (after 6 hours) |
| Inhibition Concentration | in vitro |
| Sequence | 2011 |
| Cytotoxicity | J774.A1 macrophage cell lines |
| In vivo Model | 89% bacteria is cleared |
| Lethal Dose | NA |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1397, |
| Name | 21790937 |
| N-Terminal modification | LLKKK-18 |
| C-Terminal Modification | KEFKRIVKRIKKFLRKLV |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 19 |
| Source | L |
| Origin | Cationic |
| Species | Natural |
| Strain | Murine macrophages |
| Inhibition Concentration | Mycobacteria smegmatis |
| In Vitro/ In vivo | M. smegmatis mc2 155 |
| Cell Line | MIC = 25μg/ml |
| Inhibition Concentration | in vitro |
| Sequence | 2011 |
| Cytotoxicity | J774.A1 macrophage cell lines |
| In vivo Model | 81% bacteria is cleared |
| Lethal Dose | NA |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1398, |
| Name | 21790937 |
| N-Terminal modification | LLKKK-18 |
| C-Terminal Modification | KEFKRIVKRIKKFLRKLV |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 19 |
| Source | L |
| Origin | Cationic |
| Species | Natural |
| Strain | Murine macrophages |
| Inhibition Concentration | Mycobacteria smegmatis |
| In Vitro/ In vivo | M. smegmatis mc2 155 |
| Cell Line | MIC = 25μg /ml (after 6 hours incubation) |
| Inhibition Concentration | in vitro |
| Sequence | 2011 |
| Cytotoxicity | J774.A1 macrophage cell lines |
| In vivo Model | 98% bacteria is cleared |
| Lethal Dose | NA |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1401, |
| Name | 21790937 |
| N-Terminal modification | LLKKK-18 |
| C-Terminal Modification | KEFKRIVKRIKKFLRKLV |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 19 |
| Source | L |
| Origin | Cationic |
| Species | Natural |
| Strain | Murine macrophages |
| Inhibition Concentration | Mycobacteria smegmatis |
| In Vitro/ In vivo | M. smegmatis mc2 155 |
| Cell Line | MIC = 1μg /ml |
| Inhibition Concentration | in vitro |
| Sequence | 2011 |
| Cytotoxicity | J774.A1 macrophage cell lines |
| In vivo Model | 51% bacteria is cleared |
| Lethal Dose | NA |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1402, |
| Name | 21790937 |
| N-Terminal modification | LLKKK-18 |
| C-Terminal Modification | KEFKRIVKRIKKFLRKLV |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 19 |
| Source | L |
| Origin | Cationic |
| Species | Natural |
| Strain | Murine macrophages |
| Inhibition Concentration | Mycobacteria smegmatis |
| In Vitro/ In vivo | M. smegmatis mc2 155 |
| Cell Line | MIC = 25μg/ml |
| Inhibition Concentration | in vitro |
| Sequence | 2011 |
| Cytotoxicity | J774.A1 macrophage cell lines |
| In vivo Model | 80% bacteria is cleared |
| Lethal Dose | NA |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1529, |
| Name | 25613372 |
| N-Terminal modification | LLKKK-18 |
| C-Terminal Modification | KEFKRIVKRIKKFLRKLV |
| Chemical Modification | Free |
| Linear/Cyclic | Free |
| Length | None |
| Chirality | Linear |
| Nature | 18 |
| Source | L |
| Origin | Cationic |
| Species | Protein derived |
| Strain | Derived from Human cationic antimicrobial protein 18 (hCAP18) |
| Inhibition Concentration | Mycobacterium tuberculosis |
| In Vitro/ In vivo | Mycobacterium tuberculosis H37Rv |
| Cell Line | MIC = 25 μg/ml |
| Inhibition Concentration | in vitro |
| Sequence | 2015 |
| Cytotoxicity | Human macrophage THP1 |
| In vivo Model | NA |
| Lethal Dose | No cytotoxicity |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | Induce expression of IL-8 and MCP-1 |
| Combination Therapy | In vitro binding of bacterilamembrane and induce pore formation while in vivo activate TLR and monocyte to kill bacteria |
| Other activities | Bacterial cell membrane |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |