Primary information |
---|
ID | antitb_1274, |
Name | 25759383 |
N-Terminal modification | Inhibitor 4 |
C-Terminal Modification | Ala(1-naphtyl)-K-boroLeu |
Chemical Modification | Free |
Linear/Cyclic | Free |
Length | Ala(1-naphtyl) = 1-napthylalanine, boroLeu = leucine boronic acid |
Chirality | Linear |
Nature | 3 |
Source | L |
Species | Synthetic |
Strain | substrate-based boronate inhibitors |
Inhibition Concentration | Mycobacterium tuberculosis |
In Vitro/ In vivo | Mycobacterium tuberculosis H37Rv |
Cell Line | MIC50 = 12 μM |
Inhibition Concentration | In vitro |
Sequence | 2015 |
Cytotoxicity | Myeloma cells (MM1.S) |
In vivo Model | NA |
Lethal Dose | No cytotoxicty |
Immune Responce | None |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | Inhibit ClpP1P2 peptidase activity and protein degradation in the presence of ClpC1 and ClpX ATPases. |
Other activities | ClpP1P2 peptidase |
PMID | None |
Year of Publication | None |
Tertiary Structure (Technique) | Not Predicted), |
Primary information |
---|
ID | antitb_1275, |
Name | 25759383 |
N-Terminal modification | Inhibitor 4 |
C-Terminal Modification | Ala(1-naphtyl)-K-boroLeu |
Chemical Modification | Free |
Linear/Cyclic | Free |
Length | Ala(1-naphtyl) = 1-napthylalanine, boroLeu = leucine boronic acid |
Chirality | Linear |
Nature | 3 |
Source | L |
Species | Synthetic |
Strain | substrate-based boronate inhibitors |
Inhibition Concentration | Mycobacterium smegmatis |
In Vitro/ In vivo | Mycobacterium smegmatis strain constitutively expressing GFP-ssrA |
Cell Line | MIC50 = 1.5 μM |
Inhibition Concentration | In vitro |
Sequence | 2015 |
Cytotoxicity | Myeloma cells (MM1.S) |
In vivo Model | NA |
Lethal Dose | No cytotoxicty |
Immune Responce | None |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | Inhibit ClpP1P2 peptidase activity and protein degradation in the presence of ClpC1 and ClpX ATPases. |
Other activities | ClpP1P2 peptidase |
PMID | None |
Year of Publication | None |
Tertiary Structure (Technique) | Not Predicted), |