Primary information |
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ID | antitb_1973 |
Peptide Name | Granulysin |
Sequence | RLSPEYYDLARAHLRDEEKSCPCLAQEGPQGDLLTKTQELGRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGLVAGETAQQICEDLRLCIPSTGPL |
N-terminal Modification | Free |
C-terminal Modification | Free |
Chemical Modification | None |
Linear/ Cyclic | Linear |
Length | 123 |
Chirality | Mix |
Nature | Cationic |
Source | Natural |
Origin | Homo sapiens |
Species | Mycobacterium tuberculosis |
Strain | Mycobacterium tuberculosis |
Inhibition Concentartion | 10-15% Killing |
In vitro/In vivo | In vivo |
Cell Line | CD8+ T |
Inhibition Concentartion | NA |
Cytotoxicity | NA |
In vivo Model | NA |
Lethal Dose | NA |
Immune Response | NA |
Mechanism of Action | Altering Membrane Permeability |
Target | cell wall (lipid bilayer) |
Combination Therapy | NA |
Other Activities | Cryptococcus neoformans, Candida albicans, Leishmania major, S. typhimurium, L. monocytogenes, E. coli, and Staphylococcus aureus |
Pubmed ID | 9756476 |
Year of Publication | 1988 |
3-D Structure | NA |