| Primary information |
|---|
| ID | antitb_1888 |
| Peptide Name | Trichoderins A |
| Sequence | PXXXIVXX |
| N-terminal Modification | Addition of MDA (2-methyl decanoic acid) |
| C-terminal Modification | Addition of AMAE (2-[(20-aminopropyl) methylamino] ethanol) |
| Chemical Modification | Addition of AHMOD at residue 2 (2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid) and AIB (a-aminoisobutyric acid) at 3,4,7, and 8 |
| Linear/ Cyclic | Cyclic |
| Length | 8 |
| Chirality | D |
| Nature | NA |
| Source | Natural |
| Origin | Isolated from Trichoderma species 05FI48 |
| Species | Mycobacterium bovis |
| Strain | Mycobacterium bovis BCG |
| Inhibition Concentartion | MIC = 0.16 μg/ml |
| In vitro/In vivo | In vitro |
| Cell Line | NA |
| Inhibition Concentartion | Tratment with this concentration inhibit 100% bacterial growth |
| Cytotoxicity | NA |
| In vivo Model | NA |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | NA |
| Target | Lipid bilayer |
| Combination Therapy | NA |
| Other Activities | NA |
| Pubmed ID | 20483615 |
| Year of Publication | 2010 |
| 3-D Structure | NA |