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Detailed description page of AntiTbPdb

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antitb_1887 details
Primary information
IDantitb_1887
Peptide NameTrichoderins A1
SequencePXXXIVXX
N-terminal ModificationAddition of MDA (2-methyl decanoic acid)
C-terminal ModificationAddition of AMAE (2-[(20-aminopropyl) methylamino] ethanol)
Chemical ModificationAddition of AHMOD at residue 2 (2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid) and AIB (a-aminoisobutyric acid) at 3,4,7, and 8
Linear/ CyclicCyclic
Length8
ChiralityD
NatureNA
SourceNatural
OriginIsolated from Trichoderma species 05FI48
SpeciesMycobacterium smegmatis
StrainMycobacterium smegmatis M341
Inhibition ConcentartionMIC = 1.56 μg/mL
In vitro/In vivoIn vitro
Cell LineNA
Inhibition ConcentartionTratment with this concentration inhibit 100% bacterial growth
CytotoxicityNA
In vivo ModelNA
Lethal DoseNA
Immune ResponseNA
Mechanism of ActionNA
TargetLipid bilayer
Combination TherapyNA
Other ActivitiesNA
Pubmed ID20483615
Year of Publication2010
3-D StructureNA