| Primary information |
|---|
| ID | antitb_1856 |
| Peptide Name | Hytramycin I |
| Sequence | (METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip) |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Chemical Modification | METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine |
| Linear/ Cyclic | Cyclic (Intrachain bond between 1-6) |
| Length | 6 |
| Chirality | Mix |
| Nature | NA |
| Source | Natural |
| Origin | From Streptomyces hygroscopicus strain ECUM 14046 |
| Species | Mycobacterium tuberculosis |
| Strain | Mycobacterium tuberculosis resistant to isoniazid (rINH, ATCC 35822) |
| Inhibition Concentartion | MIC = 4.7 μg/mL |
| In vitro/In vivo | In vitro |
| Cell Line | None |
| Inhibition Concentartion | NA |
| Cytotoxicity | NA |
| In vivo Model | NA |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other Activities | Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853) |
| Pubmed ID | 24224794 |
| Year of Publication | 2013 |
| 3-D Structure | NA |