Primary information |
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ID | antitb_1842 |
Peptide Name | Hytramycin V |
Sequence | (METH-Ala)-(D-Pip)-L-(D-VAL)-Pip-(D-Pip) |
N-terminal Modification | Free |
C-terminal Modification | Free |
Chemical Modification | METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties |
Linear/ Cyclic | Cyclic (Intrachain bond between 1-6) |
Length | 6 |
Chirality | Mix |
Nature | NA |
Source | Natural |
Origin | From Streptomyces hygroscopicus strain ECUM 14046 |
Species | Mycobacterium tuberculosis |
Strain | Mycobacterium tuberculosis resistant to isoniazid (rINH, ATCC 35822) |
Inhibition Concentartion | MIC = 12.1 μg/mL |
In vitro/In vivo | In vitro |
Cell Line | None |
Inhibition Concentartion | NA |
Cytotoxicity | NA |
In vivo Model | NA |
Lethal Dose | NA |
Immune Response | NA |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | NA |
Other Activities | Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853) |
Pubmed ID | 24224794 |
Year of Publication | 2013 |
3-D Structure | NA |