| Primary information |
|---|
| ID | antitb_1783 |
| Peptide Name | Peptide-27 |
| Sequence | KL-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK |
| N-terminal Modification | Free |
| C-terminal Modification | Amidation |
| Chemical Modification | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid |
| Linear/ Cyclic | Linear |
| Length | 19 |
| Chirality | L |
| Nature | Amphipathic, Hydrophobic |
| Source | Synthetic |
| Origin | NA |
| Species | Mycobacterium ranae |
| Strain | Mycobacterium ranae (ATCC 110) |
| Inhibition Concentartion | MIC = 3 µM or 7.5 µg/mL |
| In vitro/In vivo | Both |
| Cell Line | RBC |
| Inhibition Concentartion | NA |
| Cytotoxicity | 43.6 % and 24.9 % hemolytic activity at 100 µM and 25 µM peptide respectively |
| In vivo Model | mouse skin wound healing model |
| Lethal Dose | No toxicity observed at 25 mg/kg for 6 days |
| Immune Response | Stimulate innate immune system |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other Activities | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) |
| Pubmed ID | 17547385 |
| Year of Publication | 2007 |
| 3-D Structure | NA |