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Detailed description page of AntiTbPdb

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antitb_1783 details
Primary information
IDantitb_1783
Peptide NamePeptide-27
SequenceKL-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK
N-terminal ModificationFree
C-terminal ModificationAmidation
Chemical ModificationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid
Linear/ CyclicLinear
Length19
ChiralityL
NatureAmphipathic, Hydrophobic
SourceSynthetic
OriginNA
SpeciesMycobacterium ranae
StrainMycobacterium ranae (ATCC 110)
Inhibition ConcentartionMIC = 3 µM or 7.5 µg/mL
In vitro/In vivoBoth
Cell LineRBC
Inhibition ConcentartionNA
Cytotoxicity43.6 % and 24.9 % hemolytic activity at 100 µM and 25 µM peptide respectively
In vivo Modelmouse skin wound healing model
Lethal DoseNo toxicity observed at 25 mg/kg for 6 days
Immune ResponseStimulate innate immune system
Mechanism of ActionNA
TargetNA
Combination TherapyNA
Other ActivitiesAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))
Pubmed ID17547385
Year of Publication2007
3-D StructureNA