Detailed description page of AntiTbPdb
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antitb_1713 details |
| Primary information | |
|---|---|
| ID | antitb_1713 |
| Peptide Name | Ecumicin |
| Sequence | (N,N-Me2-Val)-(Val)-(N-Me-allo-Ilu)-(Thr)-(N-Me-Thr)-(Val)-(N-Me-Leu)-(Val)-(N-Me-Val)-(N-Me-4-OMe-Trp)-(Val)-(Ph-threo-Ser)-(Val) |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Chemical Modification | N-methylation pattern, N-Me-Val = N-methyl-valine, N,N-Me2-Val = N,N-dimethyl-valine, N-Me-Thr = N-methyl-threonine, N-Me-Leu = N-methyl-leucine, N-Me-allo-Ilu = N-methyl-isoleucine, N-Me-4-OMe-Trp = N-methyl-4-methoxy-tryptophan, Ph-threo-Ser = Phe |
| Linear/ Cyclic | Macrocyclic |
| Length | 13 |
| Chirality | L |
| Nature | NA |
| Source | Natural |
| Origin | Produced by a genetically distinct Nonomuraea species, strain MJM5123 |
| Species | Mycobacterium tuberculosis |
| Strain | Mycobacterium Tuberculosis H37Rv resistant to streptomycin |
| Inhibition Concentartion | IC90= < 0.20 μg/ml |
| In vitro/In vivo | Both |
| Cell Line | VERO cell line |
| Inhibition Concentartion | 50 % bacteria is killed |
| Cytotoxicity | No cytotoxicity |
| In vivo Model | NA |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other Activities | NA |
| Pubmed ID | 25409285 |
| Year of Publication | 2014 |
| 3-D Structure | NA |