| Primary information |
|---|
| ID | antitb_1651 |
| Peptide Name | Human neutrohil peptide (HNP-1) |
| Sequence | ACYCRIPACIAGERRYGTCIYQGRLWAFCC |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Chemical Modification | Disulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29 |
| Linear/ Cyclic | Cyclic |
| Length | 30 |
| Chirality | L |
| Nature | Cationic |
| Source | Synthetic |
| Origin | Human neutrophil |
| Species | Mycobacterium Tuberculosis |
| Strain | Mycobacterium tuberculosis H37Rv |
| Inhibition Concentartion | IC50 = 0.8μg/ml |
| In vitro/In vivo | in vitro |
| Cell Line | murine macrophage-like cell line J744A.1 |
| Inhibition Concentartion | NA |
| Cytotoxicity | cytotoxic at above concentration 5 ug/ml |
| In vivo Model | NA |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | Microbial membrane disruption |
| Target | NA |
| Combination Therapy | NA |
| Other Activities | NA |
| Pubmed ID | 10933095 |
| Year of Publication | 2016 |
| 3-D Structure | NA |