Primary information |
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ID | antitb_1606 |
Peptide Name | β-Defensin-1(HBD-1) |
Sequence | DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK |
N-terminal Modification | Free |
C-terminal Modification | Free |
Chemical Modification | Disulphide nlinkage between cys5-34, cys12-27, cys17-35. |
Linear/ Cyclic | Cyclic |
Length | 36 |
Chirality | L |
Nature | Cationic |
Source | Natural |
Origin | Derived from beta defensin 1 OF HUMAN |
Species | Mycobacterium tuberculosis |
Strain | Mycobacterium tuberculosis RM22 |
Inhibition Concentartion | CFU/well 0.90 ± 0.75 at peptide 64ul + 4 ul of INH |
In vitro/In vivo | in vitro |
Cell Line | NA |
Inhibition Concentartion | NA |
Cytotoxicity | NA |
In vivo Model | NA |
Lethal Dose | NA |
Immune Response | NA |
Mechanism of Action | Bacterial membrane pore formation |
Target | NA |
Combination Therapy | Peptide(64 ul) + INH(4 ul) |
Other Activities | NA |
Pubmed ID | 15245864 |
Year of Publication | 2004 |
3-D Structure | NA |