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Detailed description page of AntiTbPdb

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antitb_1537 details
Primary information
IDantitb_1537
Peptide NameHuman neutrohil peptide (HNP-1)
SequenceDCYCRIPACIAGERRYGTCIYQGRLWAFCC
N-terminal ModificationFree
C-terminal ModificationFree
Chemical ModificationDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29
Linear/ CyclicCyclic
Length30
ChiralityL
NatureCationic
SourceNatural
OriginHuman neutrophil
SpeciesMycobacterium tuberculosis
StrainMycobacterium tuberculosis H37Rv
Inhibition ConcentartionIC50= 0.0255 μg/ml
In vitro/In vivoin vitro
Cell LineNA
Inhibition ConcentartionNA
CytotoxicityNA
In vivo ModelNA
Lethal DoseNA
Immune ResponseMediate macrophage to induce TNF-α expression
Mechanism of ActionInhibit lipid biosynthesi
TargetNA
Combination TherapyHNP-1 + Isoniazid
Other ActivitiesAntibacterial against E.coli, S.aureus, bacillus, pseudomonas
Pubmed ID25613372
Year of Publication2015
3-D StructureNA