| Primary information |
|---|
| ID | antitb_1267 |
| Peptide Name | L91 |
| Sequence | SEFAYGSFVRTVSLPVGADE |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Chemical Modification | Conjugated to TLR2-ligand Pam2Cys |
| Linear/ Cyclic | Linear |
| Length | 20 |
| Chirality | L |
| Nature | NA |
| Source | Protein Derived |
| Origin | From 16kDa antigen |
| Species | None |
| Strain | None |
| Inhibition Concentartion | NA |
| In vitro/In vivo | In vivo |
| Cell Line | NA |
| Inhibition Concentartion | NA |
| Cytotoxicity | NA |
| In vivo Model | Female BALB/c mice (6-8 wk, 20±2 g) |
| Lethal Dose | 20 nmol |
| Immune Response | It promotes the maturation of MHC-II and elicit secretion of IFN-Î¥ and also induce the expression of CD80, CD86 and CD40 co-stimulatory molecules and activate DCs to produce IL-6 and IL-12. |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | None |
| Other Activities | NA |
| Pubmed ID | 24434326 |
| Year of Publication | 2013 |
| 3-D Structure |  View in Jmol or Download Structure |