Primary information |
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ID | antitb_1221 |
Peptide Name | PK34 |
Sequence | PRVIETKVHGREVTGLARNVSEENVDRLAKRWIK |
N-terminal Modification | Free |
C-terminal Modification | Free |
Chemical Modification | None |
Linear/ Cyclic | Linear |
Length | 34 |
Chirality | L |
Nature | Cationic |
Source | Synthetic |
Origin | Searched and selected from mycobacteriophage genome sequences |
Species | Mycobacterium tuberculosis |
Strain | Mycobacterium tuberculosis H37Rv strain (ATCC 27294 |
Inhibition Concentartion | MIC = 50 μg/ml |
In vitro/In vivo | Both |
Cell Line | Murine macrophage-like J774A.1 |
Inhibition Concentartion | NA |
Cytotoxicity | NA |
In vivo Model | Four-week-old female BALB/c mice |
Lethal Dose | Dose of 20 mg (5×10−6 mol)/kg BW/d, PK34 had co |
Immune Response | Inhibits the proinflammatory factor (IFN-γ, TNF-α, MCP-1, IL-6, IL-10, IL-12) production of macrophage cells induced by TDM. |
Mechanism of Action | Cell wall disruption |
Target | trehalose-6,6=-dimycolate (TDM) |
Combination Therapy | None |
Other Activities | None |
Pubmed ID | 23603838 |
Year of Publication | 2013 |
3-D Structure | View in Jmol or Download Structure |