| Primary information |
|---|
| ID | antitb_1220 |
| Peptide Name | Cathelicidin HHC-10 |
| Sequence | KRWWKWIRW |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Length | 9 |
| Chirality | L |
| Nature | Cationic |
| Source | Synthetic |
| Origin | NA |
| Species | Mycobacterium bovis |
| Strain | Mycobacterium tuberculosis complex bacteria, Mycobacterium bovis bacille calmette guerin (BCG) (Mycobacterium bovis BCG Pasteur 1173P2) |
| Inhibition Concentartion | 88 % decrease in CFU at 100 μg/ ml |
| In vitro/In vivo | Both |
| Cell Line | None |
| Inhibition Concentartion | NA |
| Cytotoxicity | NA |
| In vivo Model | 8–9 weeks old C57BL/6 mice |
| Lethal Dose | CFUs in mouse lungs were reduced 95.8% at 2.5 mg k |
| Immune Response | Significant reduction of IFN-γ transcription |
| Mechanism of Action | Cell envelope disruption |
| Target | Cell envelope |
| Combination Therapy | None |
| Other Activities | Antibacterial (such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, and S. aureus etc |
| Pubmed ID | 23231581 |
| Year of Publication | 2013 |
| 3-D Structure |  View in Jmol or Download Structure |