Primary information |
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ID | antitb_1198 |
Peptide Name | Pinanediol PD-protected Boropentapeptide |
Sequence | AVKAA-BO2(PD) |
N-terminal Modification | Free |
C-terminal Modification | Conjugated with Boronic acid and pinanediol PD |
Chemical Modification | Conjugated with Boronic acid and pinanediol PD |
Linear/ Cyclic | Linear |
Length | 5 |
Chirality | L |
Nature | NA |
Source | Synthetic |
Origin | NA |
Species | Mycobacterium thermoresistible |
Strain | Mycobacterium thermoresistible |
Inhibition Concentartion | IC50 = 121.6 ± 25.3 μM for MycP1 |
In vitro/In vivo | In vitro |
Cell Line | None |
Inhibition Concentartion | NA |
Cytotoxicity | NA |
In vivo Model | None |
Lethal Dose | NA |
Immune Response | NA |
Mechanism of Action | Inhibit enzyme (MycP1) reponsible for cleavage of virulence factor (ESX secretion-associated protein B (EspB)) |
Target | Mycosin protease-1 (MycP1) |
Combination Therapy | None |
Other Activities | None |
Pubmed ID | 24915878 |
Year of Publication | 2014 |
3-D Structure | View in Jmol or Download Structure |