| Primary information |
|---|
| ID | antitb_1187 |
| Peptide Name | Pin2 [G] |
| Sequence | FWGALAKGALKLIGSLFSSFSKKD |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Length | 24 |
| Chirality | L |
| Nature | Cationic |
| Source | Synthetic |
| Origin | Amino acid substitution at one postion of Pin2 (P at 14 by G) |
| Species | Mycobacterium tuberculosis |
| Strain | Mycobacterium tuberculosis H37Rv |
| Inhibition Concentartion | MIC = 48.1 μg/ml or 18.7 μM |
| In vitro/In vivo | In vitro |
| Cell Line | RBC |
| Inhibition Concentartion | NA |
| Cytotoxicity | Hemolysis ( IC-50 = 1.4 [0.4–4.3] ) |
| In vivo Model | None |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | Cell wall disruption |
| Target | Cell wall |
| Combination Therapy | None |
| Other Activities | Anti-bacterial (E. coli, S. aureus) |
| Pubmed ID | 25019413 |
| Year of Publication | 2014 |
| 3-D Structure |  View in Jmol or Download Structure |