Primary information |
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ID | antitb_1185 |
Peptide Name | Pin2 |
Sequence | FWGALAKGALKLIPSLFSSFSKKD |
N-terminal Modification | Free |
C-terminal Modification | Free |
Chemical Modification | None |
Linear/ Cyclic | Linear |
Length | 24 |
Chirality | L |
Nature | Cationic |
Source | Natural |
Origin | Venom of the African scorpion Pandinus imperator |
Species | Mycobacterium tuberculosis |
Strain | Mycobacterium tuberculosis H37Rv |
Inhibition Concentartion | MIC = 57.7 ± 22.3 μg/ml or 22.1 ± 8.6 μM |
In vitro/In vivo | In vitro |
Cell Line | RBC |
Inhibition Concentartion | NA |
Cytotoxicity | Hemolysis ( IC-50 = 3.3 [1.9–5.7]) |
In vivo Model | None |
Lethal Dose | NA |
Immune Response | NA |
Mechanism of Action | Cell wall disruption |
Target | Cell wall |
Combination Therapy | None |
Other Activities | Anti-bacterial (E. coli, S. aureus) |
Pubmed ID | 25019413 |
Year of Publication | 2014 |
3-D Structure | View in Jmol or Download Structure |