Primary information |
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ID | antitb_1132 |
Peptide Name | Human neutrophil defensin (HNP-1) |
Sequence | ACYCRIPACIAGERRYGTCIYQGRLWAFCC |
N-terminal Modification | Free |
C-terminal Modification | Free |
Chemical Modification | Internal disulphide bond (cys2-cys30, cys4-cys19,cys9-cys29) |
Linear/ Cyclic | Cyclic |
Length | 30 |
Chirality | L |
Nature | Cationic |
Source | Protein Derived |
Origin | From the human defensin protein found in granules of neutrophils. |
Species | Mycobacterium tuberculosis |
Strain | Mycobacterium tuberculosis H37Rv (ATCC 25618) |
Inhibition Concentartion | 50 mg/L causes approx 70 % growth inhibition |
In vitro/In vivo | In vitro |
Cell Line | None |
Inhibition Concentartion | NA |
Cytotoxicity | NA |
In vivo Model | None |
Lethal Dose | NA |
Immune Response | NA |
Mechanism of Action | Disrupt the membrane architecture |
Target | Cell envelope |
Combination Therapy | None |
Other Activities | Antibacterial against salmonella, staphylococcus and neisseria |
Pubmed ID | 11328767 |
Year of Publication | 2001 |
3-D Structure | NA |