| Primary information |
|---|
| ID | antitb_1127 |
| Peptide Name | PR-39 |
| Sequence | RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP |
| N-terminal Modification | Free |
| C-terminal Modification | Amidation |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Length | 39 |
| Chirality | L |
| Nature | Amphipathic |
| Source | Natural |
| Origin | Isolated from porcine leucocytes |
| Species | Mycobacterium tuberculosis |
| Strain | Mycobacterium tuberculosis E1380/94 MDR (Isoniazid, rifampicin, streptomycin, ethambutol) strain |
| Inhibition Concentartion | MIC50 = 93 ± 12 mg/L |
| In vitro/In vivo | In vitro |
| Cell Line | None |
| Inhibition Concentartion | NA |
| Cytotoxicity | NA |
| In vivo Model | None |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | Disrupt the membrane architecture |
| Target | Cell envelope |
| Combination Therapy | None |
| Other Activities | Antibacterial against salmonella, staphylococcus and neisseria |
| Pubmed ID | 11328767 |
| Year of Publication | 2001 |
| 3-D Structure | NA |