Primary information |
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ID | antitb_1126 |
Peptide Name | PR-39 |
Sequence | RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP |
N-terminal Modification | Free |
C-terminal Modification | Amidation |
Chemical Modification | None |
Linear/ Cyclic | Linear |
Length | 39 |
Chirality | L |
Nature | Amphipathic |
Source | Natural |
Origin | Isolated from porcine leucocytes |
Species | Mycobacterium tuberculosis |
Strain | Mycobacterium tuberculosis E1380/94 MDR (Isoniazid, rifampicin, streptomycin, ethambutol) strain |
Inhibition Concentartion | 50 mg/L causes 39 % growth inhibition |
In vitro/In vivo | In vitro |
Cell Line | None |
Inhibition Concentartion | NA |
Cytotoxicity | NA |
In vivo Model | None |
Lethal Dose | NA |
Immune Response | NA |
Mechanism of Action | Disrupt the membrane architecture |
Target | Cell envelope |
Combination Therapy | None |
Other Activities | Antibacterial against salmonella, staphylococcus and neisseria |
Pubmed ID | 11328767 |
Year of Publication | 2001 |
3-D Structure | NA |