| Primary information |
|---|
| ID | antitb_1115 |
| Peptide Name | Seq 46 |
| Sequence | RTKKWIVWI |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Length | 9 |
| Chirality | L |
| Nature | Cationic |
| Source | Synthetic |
| Origin | NA |
| Species | Mycobacterium tuberculosis |
| Strain | Mycobacterium tuberculosis H37Rv, and the Mycobacterium tuberculosis lux strain |
| Inhibition Concentartion | MIC90 = 78.1 μM |
| In vitro/In vivo | In vitro |
| Cell Line | THP-1 cells |
| Inhibition Concentartion | NA |
| Cytotoxicity | For THP-1 (infected wth M.tb) IC50 = 208.3 μM |
| In vivo Model | None |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | None |
| Other Activities | Antibacterial and Antifungal (P. aeruginosa, Escherichia coli, Salmonella enterica serovar Typhimurium, Candida albicans, Streptococcus epidermidis, Staphylococcus aureus, and Enterococcus faecalis) |
| Pubmed ID | 23478953 |
| Year of Publication | 2013 |
| 3-D Structure |  View in Jmol or Download Structure |