Welcome to Entry Card of Peptide

Details of TopicalPdb ID 1649

PRIMARY INFORMATION

1649

PMID

12396742

Year

2002

Sequence

MALWMRLLPLLALLAL
WGPDPAAAFVNQHLCGSH
LVEALYLVCGERGFFYTPKTR
REAEDLQVGQVELGGGPG
AGSLQPLALEGSLQKRG
IVEQCCTSICSLYQLENYCN

Name

Recombinant human insulin

Length

N-Terminal Modification

Free

C-Terminal Modification

Free

Linear/ Cyclic

Linear

Chirality

Chemical Modification

None

Origin of Peptide

Synthetic

Nature of Peptide/Cargo

Not mentioned

Mechanism

Not mentioned

Cargo Sequence/Structure

Insulin was encapsulated into biphasic delivery system.

Name of cargo

Not applicable

Assay

ELISA

Enhancer

None

Properties of enhancer

Not applicable

Concentration

10 mg

Incubation time

48 hours

Tissue permeability (value with units)

A decrease in blood glucose of 43.7 +- 3.8% was observed as compared with initial blood glucose levels.

Tissue Sample

abdominal skin of streptozotocin-induced diabetic rats

Ex vivo/In vivo/In vitro

in vitro

SECONDARY INFORMATION

STRUCTURE

Predicted Structure

SMILES

N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)
N1[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
NCC(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@@H]
3C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)NCC
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N4[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)NCC(=O)NCC(=O)NCC(=O)N5[C@H](C(=O)NCC(=O)N[C@H]
(C(=O)NCC(=O)N[C@H](