| PRIMARY INFORMATION |
|---|
| ID | 1628 |
| PMID | 3095533 |
| Year | 1986 |
| Sequence | L-proglutamyl-L histidyl – L proline amide |
| Name | Thyrotropin releasing hormone(TRH) |
| Length | 3 |
| N-Terminal Modification | acyl group |
| C-Terminal Modification | Amidation |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | None |
| Origin of Peptide | synthetic |
| Nature of Peptide/Cargo | model peptide for in vitro passive and iontophoretic diffusion. |
| Mechanism | Not mentioned |
| Cargo Sequence/Structure | No cargo |
Name of cargo
| Not applicable |
| Assay | HPLC |
| Enhancer | phosphate:citrate buffer with an ionic strength of ~0.6 M.pH 4 or pH 8 |
| Properties of enhancer | Lowest value which gave sufficient buffering capacity at both pH 4 and 8. |
| Concentration | 8.8nM |
| Incubation time | 12 hrs |
| Tissue permeability (value with units) | with time all observed peaks, except the TRH peak became smaller as subsequent receptor cell samples were analyzed due to material being leached out of the excised tissue. |
| Tissue Sample | nude mouse skin |
| Ex vivo/In vivo/In vitro | in vitro |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
