| ID | 1604 | |
| PMID | 27405275 | |
| Year | 2016 | |
| Sequence | IRIKIRIK | |
| Name | D-IK8 | |
| Length | 8 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Synthetic peptide | |
| Nature of Peptide/Cargo | Distrups the mature biofilms of Staphylococci and are able to kill intracellular staphylococci at a more significant rate than other antibiotics. | |
| Mechanism | Not mentioned | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Combination assay and ELISA | |
| Enhancer | PBS | |
| Properties of enhancer | Not mentioned | |
| Concentration | 2% D-IK8 formulated in 20mg petroleum jelly | |
| Incubation time | 48 hrs | |
| Tissue permeability (value with units) | Led to increased uptake and binding of fluorscently labeled vancomycin. | |
| Tissue Sample | Mouse skin | |
| Ex vivo/In vivo/In vitro | in vitro | |
| STRUCTURE |
| |
| SMILES | N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC (=[NH2])N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H] (CCCC[NH3])C(=O)N[C@@H]([C@@H](C)CC)C(=O) N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H]([C@@H] (C)CC)C(=O)N[C@@H](CCCC[NH3])C=O | |