Welcome to Entry Card of Peptide

Details of TopicalPdb ID 1601

PRIMARY INFORMATION
ID	1601
PMID	25499919
Year	2015
Sequence	ACKTGSHNQCG
Name	DLP (Dermis localizing peptide)
Length	11
N-Terminal Modification	Free
C-Terminal Modification	Free
Linear/ Cyclic	Linear
Chirality	L
Chemical Modification	None
Origin of Peptide	Synthetic
Nature of Peptide/Cargo	Not mentioned
Mechanism	Not mentioned
Cargo Sequence/Structure	CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
Name of cargo	Cyclosporine A (CsA)
Assay	Tape-Stripping, Franz diffusion cells
Enhancer	Ethanol/PBS,pH 7.4
Properties of enhancer	Not mentioned
Concentration	25mg/ml
Incubation time	24hrs
Tissue permeability (value with units)	>10 - <15% CsA applied penetrated into the skin
Tissue Sample	Porcine skin
Ex vivo/In vivo/In vitro	in vitro
SECONDARY INFORMATION
STRUCTURE	Predicted Structure
SMILES	N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H] (CCCC[NH3])C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N [C@@H](CO)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N [C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O) N[C@@H](CS)C(=O)NCC=O