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Details of TopicalPdb ID 1595

PRIMARY INFORMATION
ID1595
PMID25734358
Year2015
SequenceACSSSPSKHCG
NameTD1
Length11
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicCyclic
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic peptide
Nature of Peptide/CargoFacilitates the trans-dermal delivery of macromolecules
MechanismTD1 mainly interacted with the C-terminus of ATP1B1.opens the skin barrier transiently,shows a saturating dose response curve,and enters the skin regardless of the presence of hair follicles.
Cargo Sequence/StructureMALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
Name of cargo
Insulin
Assayfluorescent microscopy
EnhancerPBS/ethanol solution
Properties of enhancerNot mentioned
Concentration100mg of TD-1
Incubation time2 hrs
Tissue permeability (value with units)Had both insulin elevating and (2.33-2.65 ng/ml) and glucose lowering effects.
Tissue Sampleabdominal skin of rats
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)
[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]
2N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]
(NC1=O)CO)CO)CO)CCC2)CO)CCCC[NH3])
Cc1nc[nH]c1)C(=O)NCC=O