| ID | 1594 | |
| PMID | 25734358 | |
| Year | 2015 | |
| Sequence | ACSSSPSKHCG | |
| Name | TD1 | |
| Length | 11 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Cyclic | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Synthetic peptide | |
| Nature of Peptide/Cargo | Facilitates the trans-dermal delivery of macromolecules | |
| Mechanism | TD1 mainly interacted with the C-terminus of ATP1B1.opens the skin barrier transiently,shows a saturating dose response curve,and enters the skin regardless of the presence of hair follicles. | |
| Cargo Sequence/Structure | MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN | |
| Name of cargo | Insulin | |
| Assay | fluorescent microscopy | |
| Enhancer | PBS/ethanol solution | |
| Properties of enhancer | Not mentioned | |
| Concentration | 20mg of TD-1 (topically coadministered with 70 mg of insulin) | |
| Incubation time | 2 hrs | |
| Tissue permeability (value with units) | Insulin levels elevated(0.92 -1.17ng/ml) without affecting glucose levels. | |
| Tissue Sample | abdominal skin of rats | |
| Ex vivo/In vivo/In vitro | in vitro | |
| STRUCTURE |
| |
| SMILES | N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O) [C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H] 2N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H] (NC1=O)CO)CO)CO)CCC2)CO)CCCC[NH3]) Cc1nc[nH]c1)C(=O)NCC=O | |