Welcome to Entry Card of Peptide

Details of TopicalPdb ID 1583

PRIMARY INFORMATION
ID	1583
PMID	24637683
Year	2014
Sequence	KFFKKLKNSVKKRAK KFFKKPRVIGVSIPF
Name	OH-CATH30
Length	30
N-Terminal Modification	Free
C-Terminal Modification	Free
Linear/ Cyclic	Linear
Chirality	L
Chemical Modification	None
Origin of Peptide	Naturally occurs in King Cobra
Nature of Peptide/Cargo	Cationic peptide of cathelicidin family. Exerts potent antibacterial activity, selective immunomodulatory properties and low toxicity to eukaryotic cells
Mechanism	Naturally occurs in King Cobra
Cargo Sequence/Structure	None
Name of cargo	Not applicable
Assay	Time kill assay, Clinical and histological examination, Measurement of bacterial burden
Enhancer	P.aeruginosa 447 was used to induce bacterial keratitis
Properties of enhancer	Not mentioned
Concentration	20 µl drop of 1 mg/ml concentration of peptide and 20 µl drop of 1 mg/ml concentration of Levofloxacin
Incubation time	1 hour
Tissue permeability (value with units)	Mean clinical score: OH-CATH30-0.8; PBS-2.25; Levofloxacin-1.4 ; OH-CATH30+Levofloxacin-0.7, where, 0= clear;1= slight opacity partially or fully covering the pupil;2= slight opacity fully covering the anterior segment;3= dense opacity partially or fully covering the pupil and 4= dense opacity covering the anterior segment and corneal perforation
Tissue Sample	Cornea
Ex vivo/In vivo/In vitro	in vitro
SECONDARY INFORMATION
STRUCTURE	Predicted Structure
SMILES	N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H] (C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H] (C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)N [C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)N[C@H](C=O) Cc3ccccc3)CCC2)[C@H](CC)C)CO)C(C)C)[C@H](CC)C)C(C)C) CCCNC(=N)N)CCC1)CCCCN)CCCCN)Cc1ccccc1)Cc1ccccc1) CCCCN)CCCCN)C)CCCNC(=N)N)CCCCN)CCCCN)C(C)C) CO)CC(=O)N)CCCCN)CC(C)C)CCCCN)CCCCN)Cc1ccccc1) Cc1ccccc1)CCCCN