| ID | 1574 | |
| PMID | 24637683 | |
| Year | 2014 | |
| Sequence | KFFKKLKNSVKKRAK KFFKKPRVIGVSIPF | |
| Name | OH-CATH30 | |
| Length | 30 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Naturally occurs in King Cobra | |
| Nature of Peptide/Cargo | Cationic peptide of cathelicidin family. Exerts potent antibacterial activity, selective immunomodulatory properties and low toxicity to eukaryotic cells | |
| Mechanism | Naturally occurs in King Cobra | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Time kill assay, Clinical and histological examination, Measurement of bacterial burden | |
| Enhancer | P.aeruginosa 447 was used to induce bacterial keratitis | |
| Properties of enhancer | Not mentioned | |
| Concentration | 0.5xMIC where MIC of OH-CATH30 is=6.25µg/ml, 0.5xMIC of Levofloxacin(LEV) where MIC of LEV is=125µg/ml | |
| Incubation time | 1 hour | |
| Tissue permeability (value with units) | Time kill assay of OH-CATH30:4.4 Log10 (cfu/ml); Control(PBS):6.1 Log10 (cfu/ml); Levofloxacin:5.7 Log10 (cfu/ml); OH-CATH30+Levofloxacin:4.8 Log10 (cfu/ml) | |
| Tissue Sample | Cornea | |
| Ex vivo/In vivo/In vitro | in vitro | |
| STRUCTURE |
| |
| SMILES | N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H] (C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H] (C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)N [C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)N[C@H](C=O) Cc3ccccc3)CCC2)[C@H](CC)C)CO)C(C)C)[C@H](CC)C)C(C)C) CCCNC(=N)N)CCC1)CCCCN)CCCCN)Cc1ccccc1)Cc1ccccc1) CCCCN)CCCCN)C)CCCNC(=N)N)CCCCN)CCCCN)C(C)C) CO)CC(=O)N)CCCCN)CC(C)C)CCCCN)CCCCN)Cc1ccccc1) Cc1ccccc1)CCCCN | |