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Details of TopicalPdb ID 1542

PRIMARY INFORMATION
ID1542
PMID22386653
Year2012
SequenceHLTFPLD
NameP5-1 (381–387 residue of full-length PEDF protein)
Length7
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptidePEDF derived peptide
Nature of Peptide/CargoNot mentioned
MechanismPEDF derived peptide
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayVEGF and 8-OHdG Immunostaining, Measurement of corneal neo-vascularization via avidin-biotin-alkaline phosphatase kit and statistical analysis
EnhancerNone
Properties of enhancerNot applicable
Concentration100µM PEDF peptide thrice a day for 7 days
Incubation time7 Days
Tissue permeability (value with units)Neo-vascularized area=82% of PBS on day 7(Control=4% of PBS); Oxidative stress generation, 8-OHdG level=80% of PBS (Control=50% of PBS); VEGF expression, VEGF level=73% of PBS (Control=40% of PBS)
Tissue SampleSeven week-old male Spraque–Dawley rat's right eye was used as test and left eye considered as control (PBS)
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](CC(C)C)C(=O)
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C
(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N
[C@@H](CC(=O)O)C=O