| ID | 1540 | |
| PMID | 22386653 | |
| Year | 2012 | |
| Sequence | QNPASPPEEGSPDPDSTGA LVEEEDPFFKVPVNKLA AAVSNFGYDLYRVRSSTS PTTNVLLSPLSVATAL SALSLGAEQRTESIIHR ALYYDLISSPDIHGTYKEL LDTVTAPQKNLKSAS RIVFEKKLRIKSSFVAPLE KSYGTRPRVLTGNP RLDLQEINNWVQAQ MKGKLARSTKEIPDEIS ILLLGVAHFKGQWVTKF DSRKTSLEDFYLDEER TVRVPMMSDPKAVLR YGLDSD | |
| Name | PEDF (Pigment epithelium-derived factor) | |
| Length | 399 | |
| N-Terminal Modification | Pyrrolidone carboxylic acid | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | Glycosylation at 266th residue, phosphoserine at 5, 95 and 108th residue | |
| Origin of Peptide | Neurotrophic protein | |
| Nature of Peptide/Cargo | It induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. | |
| Mechanism | Neurotrophic protein | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | VEGF and 8-OHdG Immunostaining, Measurement of corneal neo-vascularization via avidin-biotin-alkaline phosphatase kit and statistical analysis | |
| Enhancer | None | |
| Properties of enhancer | Not applicable | |
| Concentration | 1 eye drop of 1 µM thrice a day for 4 days | |
| Incubation time | 4 Days | |
| Tissue permeability (value with units) | Neo-vascularized area= 18% due to PEDF (PBS=20%) | |
| Tissue Sample | Seven week-old male Spraque–Dawley rat's right eye was used as test and left eye considered as control (PBS) | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
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| SMILES | N.A. | |