| ID | 1537 | |
| PMID | 21310913 | |
| Year | 2011 | |
| Sequence | ALTVNTNIASLNTQRNLNNS SASLNTSLQRLSTGSRINSAKD DAAGLQIANRLTSQVNGL NVATKNANDGISLAQT AEGALQQSTNILQRMRDL SLQSANGSNSDSERTALN GEVKQLQKELDRISNTTTFGG RKLLDGSFGVASFQVG SAANEIISVGIDEMSAES LNGTYFKADGGGAVTAAT ASGTVDIAIGITGGSAVNV KVDMKGNETAEQAA AKIAAAVNDANVGI GAFSDGDTISY | |
| Name | Flagellin | |
| Length | 393 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Flagellin was prepared from P. aeruginosa strain PA01 or PAK | |
| Nature of Peptide/Cargo | Topical flagellin enhanced innate immunity and protected injured corneas from C. albicans keratitis in a TLR5-dependent manner | |
| Mechanism | Flagellin was prepared from P. aeruginosa strain PA01 or PAK | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Fungal load determination, Myeloperoxidase(MPO) determination and Cytokine ELISA measurement | |
| Enhancer | PBS | |
| Properties of enhancer | Not mentioned | |
| Concentration | 500ng in 5µl of PBS | |
| Incubation time | 5 day post-infection | |
| Tissue permeability (value with units) | Camp-/- mouse corneas were more susceptible than the wild type to C. albicans. Mean clinical scores after infection with 1.0*105 CFU of C. albicans are: Wild type-9.1, KO-11.9 | |
| Tissue Sample | Eyes of Camp-/- [CRAMP-deficient] mouse breeding pairs on a B6 background | |
| Ex vivo/In vivo/In vitro | in vitro | |
| STRUCTURE |
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| SMILES | N.A. | |