Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1536

PRIMARY INFORMATION
ID1536
PMID21310913
Year2011
SequenceALTVNTNIASLNTQRNLNNS
SASLNTSLQRLSTGSRINSAKD
DAAGLQIANRLTSQVNGL
NVATKNANDGISLAQT
AEGALQQSTNILQRMRDL
SLQSANGSNSDSERTALN
GEVKQLQKELDRISNTTTFGG
RKLLDGSFGVASFQVG
SAANEIISVGIDEMSAES
LNGTYFKADGGGAVTAAT
ASGTVDIAIGITGGSAVNV
KVDMKGNETAEQAA
AKIAAAVNDANVGI
GAFSDGDTISY
NameFlagellin
Length393
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideFlagellin was prepared from P. aeruginosa strain PA01 or PAK
Nature of Peptide/CargoTopical flagellin enhanced innate immunity and protected injured corneas from C. albicans keratitis in a TLR5-dependent manner
MechanismFlagellin was prepared from P. aeruginosa strain PA01 or PAK
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayFungal load determination, Myeloperoxidase(MPO) determination and Cytokine ELISA measurement
EnhancerPBS
Properties of enhancerNot mentioned
Concentration500ng in 5µl of PBS
Incubation time3 day post-infection
Tissue permeability (value with units)Camp-/- mouse corneas were more susceptible than the wild type to C. albicans. Mean clinical scores after infection with 1.0*105 CFU of C. albicans are: Wild type-9.3, KO-12
Tissue SampleEyes of Camp-/- [CRAMP-deficient] mouse breeding pairs on a B6 background
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.