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Details of TopicalPdb ID 1532

PRIMARY INFORMATION
ID1532
PMID21310913
Year2011
SequenceALTVNTNIASLNTQRNLNNS
SASLNTSLQRLSTGSRINSAKD
DAAGLQIANRLTSQVNGL
NVATKNANDGISLAQT
AEGALQQSTNILQRMRDL
SLQSANGSNSDSERTALN
GEVKQLQKELDRISNTTTFGG
RKLLDGSFGVASFQVG
SAANEIISVGIDEMSAES
LNGTYFKADGGGAVTAAT
ASGTVDIAIGITGGSAVNV
KVDMKGNETAEQAA
AKIAAAVNDANVGI
GAFSDGDTISY
NameFlagellin
Length393
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideFlagellin was prepared from P. aeruginosa strain PA01 or PAK
Nature of Peptide/CargoTopical flagellin enhanced innate immunity and protected injured corneas from C. albicans keratitis in a TLR5-dependent manner
MechanismFlagellin was prepared from P. aeruginosa strain PA01 or PAK
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayFungal load determination, Myeloperoxidase(MPO) determination and Cytokine ELISA measurement
EnhancerPBS
Properties of enhancerNot mentioned
Concentration500ng in 5µl of PBS
Incubation time1 day post-infection
Tissue permeability (value with units)Camp-/- mouse corneas were more susceptible than the wild type to C. albicans. Mean clinical scores after infection with 1.0*104 CFU of C. albicans are: Wild type-5.3, KO-9.4
Tissue SampleEyes of Camp-/- [CRAMP-deficient] mouse breeding pairs on a B6 background
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.