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Details of TopicalPdb ID 1531

PRIMARY INFORMATION
ID1531
PMID21310913
Year2011
SequenceALTVNTNIASLNTQRNLNNS
SASLNTSLQRLSTGSRINSAKD
DAAGLQIANRLTSQVNGL
NVATKNANDGISLAQT
AEGALQQSTNILQRMRDL
SLQSANGSNSDSERTALN
GEVKQLQKELDRISNTTTFGG
RKLLDGSFGVASFQVG
SAANEIISVGIDEMSAES
LNGTYFKADGGGAVTAAT
ASGTVDIAIGITGGSAVNV
KVDMKGNETAEQAA
AKIAAAVNDANVGI
GAFSDGDTISY
NameFlagellin
Length393
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideFlagellin was prepared from P. aeruginosa strain PA01 or PAK
Nature of Peptide/CargoTopical flagellin enhanced innate immunity and protected injured corneas from C. albicans keratitis in a TLR5-dependent manner
MechanismFlagellin was prepared from P. aeruginosa strain PA01 or PAK
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayFungal load determination, Myeloperoxidase(MPO) determination and Cytokine ELISA measurement
EnhancerPBS
Properties of enhancerNot mentioned
Concentration500ng in 5µl of PBS
Incubation time3 day post-infection
Tissue permeability (value with units)Clinical score: Flagellin-11.1/PBS-10.9; CFU(1000) of C. albicans per cornea-Flagellin-3.4/PBS-4.2; MPO activity per cornea: Flagellin-23/PBS-19.
Tissue SampleEyes of TLR5-/- mouse breeding pairs
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.