Welcome to Entry Card of Peptide

Details of TopicalPdb ID 1435

PRIMARY INFORMATION
ID	1435
PMID	2365569
Year	1990
Sequence	YVMGHFRWDRFG
Name	ƴ-MSH (ƴ-Melanocyte-stimulating hormone)
Length	12
N-Terminal Modification	Free
C-Terminal Modification	Free
Linear/ Cyclic	Linear
Chirality	L
Chemical Modification	None
Origin of Peptide	The melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides
Nature of Peptide/Cargo	MSH stimulate the production and release of melanin (a process referred to as melanogenesis) by melanocytes in skin and hair. MSH actions in the brain have effects on appetite and sexual arousal.
Mechanism	The melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides
Cargo Sequence/Structure	None
Name of cargo	Not applicable
Assay	Osmolarity and tear volume measurements
Enhancer	The osmolarity of the solution was 302 mOsm/1, and the pH was 7.4. Aliquots of peptide stock solutions were stored at -80°C until used
Properties of enhancer	Not mentioned
Concentration	10-3 M
Incubation time	0minutes, 6 minutes and 16 minutes for osmolarity measurement and 5-6 minutes for volume measurement
Tissue permeability (value with units)	Osmolarity measurements: t=0 min., ƴ-MSH/Buffer=311/312.5mOsm/l; t=6 min., ƴ-MSH/Buffer=303/306mOsm/l; t=16 min., ƴ-MSH/Buffer=307/309mOsm/l; Volume measurement: ƴ-MSH/Buffer= 12µl/6µl
Tissue Sample	Eyes of male and female New Zealand white rabbits with closed lacrimal gland excretory duct
Ex vivo/In vivo/In vitro	in vivo
SECONDARY INFORMATION
STRUCTURE	Predicted Structure
SMILES	N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O) N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](Cc1nc[nH]c1)C(=O) N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=[NH2])N) C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC (=O)O)C(=O)N[C@@H](CCCNC(=[NH2])N) C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC=O