Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1435

PRIMARY INFORMATION
ID1435
PMID2365569
Year1990
SequenceYVMGHFRWDRFG
Nameƴ-MSH (ƴ-Melanocyte-stimulating hormone)
Length12
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideThe melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides
Nature of Peptide/CargoMSH stimulate the production and release of melanin (a process referred to as melanogenesis) by melanocytes in skin and hair. MSH actions in the brain have effects on appetite and sexual arousal.
MechanismThe melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayOsmolarity and tear volume measurements
EnhancerThe osmolarity of the solution was 302 mOsm/1, and the pH was 7.4. Aliquots of peptide stock solutions were stored at -80°C until used
Properties of enhancerNot mentioned
Concentration10-3 M
Incubation time0minutes, 6 minutes and 16 minutes for osmolarity measurement and 5-6 minutes for volume measurement
Tissue permeability (value with units)Osmolarity measurements: t=0 min., ƴ-MSH/Buffer=311/312.5mOsm/l; t=6 min., ƴ-MSH/Buffer=303/306mOsm/l; t=16 min., ƴ-MSH/Buffer=307/309mOsm/l; Volume measurement: ƴ-MSH/Buffer= 12µl/6µl
Tissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory duct
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)
N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](Cc1nc[nH]c1)C(=O)
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=[NH2])N)
C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC
(=O)O)C(=O)N[C@@H](CCCNC(=[NH2])N)
C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC=O