Welcome to Entry Card of Peptide

Details of TopicalPdb ID 1433

PRIMARY INFORMATION
ID	1433
PMID	2365569
Year	1990
Sequence	SYSMEHFRWGKPV
Name	α-MSH (α-Melanocyte-stimulating hormone )
Length	13
N-Terminal Modification	Acetylation
C-Terminal Modification	Free
Linear/ Cyclic	Linear
Chirality	L
Chemical Modification	None
Origin of Peptide	The melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides
Nature of Peptide/Cargo	It acts as an antagonist to interleukin 1 (IL-1) bioactivities such as inhibition of fever production, thymocyte proliferation, and inhibition of release of acute phase inflammatory molecules from the liver.
Mechanism	The melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides
Cargo Sequence/Structure	None
Name of cargo	Not applicable
Assay	Osmolarity and tear volume measurements
Enhancer	The osmolarity of the solution was 302 mOsm/1, and the pH was 7.4. Aliquots of peptide stock solutions were stored at -80°C until used
Properties of enhancer	Not mentioned
Concentration	10-4 M
Incubation time	0minutes, 6 minutes and 16 minutes for osmolarity measurement and 5-6 minutes for volume measurement
Tissue permeability (value with units)	Osmolarity measurements: t=0 min., α-MSH/Buffer=310/311mOsm/l; t=6 min., α-MSH/Buffer=301/306mOsm/l; t=16 min., α-MSH/Buffer=305/308mOsm/l; Volume measurement: α-MSH/Buffer= 17.5µl/6.2µl
Tissue Sample	Eyes of male and female New Zealand white rabbits with closed lacrimal gland excretory duct
Ex vivo/In vivo/In vitro	in vivo
SECONDARY INFORMATION
STRUCTURE	Predicted Structure
SMILES	CC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O) cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O) N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O) N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=[NH2]) N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC (=O)N[C@@H](CCCC[NH3])C(=O)N1CCC [C@H]1C(=O)N[C@@H](C(C)C)C=O